Eukaryotes contain overlapping genetic information
the verdict
SUPPORTED
the evidence backs this
confidence 88/100
Multiple genomic studies confirm that eukaryotic genomes contain overlapping genes, open reading frames, and transcripts sharing common genomic sequences.
Evidence for · 5
Overlapping genes in natural and engineered genomes
2021 · cited by 109
Reviews how overlapping genes, open reading frames, and coding sequences are widespread and functionally integrated into eukaryotic genomes.
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More for · 4
Overlapping genes in the human and mouse genomes
2008 · cited by 74
Identifies overlapping genes in human and mouse genomes, showing that about 10% of the genes under study are overlapping.
An Overview of Nested Genes in Eukaryotic Genomes
2009 · cited by 68
Discusses the organizational arrangement in eukaryotic genomes where gene-coding sequences overlap and genomic segments encode more than one gene product.
Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56 419 completely sequenced and manually annotated full-length cDNAs
2006 · cited by 47
Identifies alternative splicing patterns and overlapping protein coding sequences of different reading frames in human transcripts.
Mechanism of expression regulation of head-to-head overlapping protein-coding genes INO80E and HIRIP3
2025 · cited by 2
Examines the existence and regulatory role of head-to-head overlapping protein-coding genes in eukaryotic genomes.