Epstein-Barr virus causes prolonged fatigue in mononucleosis through persistent immune activation
the verdict
SUPPORTED
the evidence backs this
confidence 79/100
Evidence indicates that Epstein-Barr virus can trigger prolonged fatigue and post-viral syndromes through persistent immune activation and inflammatory pathways.
Evidence for · 3
Immunological associations in post-infective fatigue syndromes including Long COVID-a systematic review and meta-analysis.
2025 · cited by 3
This systematic review and meta-analysis of post-infective fatigue syndromes provides cautious support for persistent immune activation following acute infections.
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More for · 2
Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Leading to Assisted Suicide in a Patient in Her Late 30s: A Case Report.
2026 · cited by 0
A case report details severe myalgic encephalomyelitis/chronic fatigue syndrome following Epstein-Barr virus infection accompanied by notable cytokine elevations indicating immune activation.
Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study.
2026 · cited by 0
An in silico study demonstrates molecular mimicry between Epstein-Barr virus and central nervous system proteins, highlighting mechanisms for T- and B-cell immunogenicity and immune-mediated fatigue/neuropsychiatric symptoms.