Epigenetic memory mechanisms are actively expressed in mammalian neurons
Multiple peer-reviewed studies establish that epigenetic memory mechanisms, such as DNA methylation, histone modification, and chromatin remodeling, are actively expressed and function in mammalian neurons to regulate synaptic plasticity and memory formation.
The retrieved papers provide robust, direct evidence that epigenetic mechanisms like DNA methylation, histone acetylation, and chromatin remodeling operate within mammalian neurons to support brain plasticity and memory. Papers 0, 1, 2, 3, and 4 all specifically address mammalian neurons and document active epigenetic regulation, directly supporting the claim. None of the papers refute the claim.
Hongda Li, Xiaofen Zhong, Kevin F. Chau, Emily C Williams, Q. Chang. Loss of Activity-Induced Phosphorylation of MeCP2 Enhances Synaptogenesis, LTP, and Spatial Memory. 2011. https://doi.org/10.1038/nn.2866
Demonstrates that DNA methylation-dependent epigenetic mechanisms and MeCP2 phosphorylation regulate mammalian neuronal function and memory.
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Manabu Fuchikami, Shigeto Yamamoto, S. Morinobu, Shiro Takei, S. Yamawaki. Epigenetic Regulation of BDNF Gene in Response to Stress. 2010. https://doi.org/10.4306/pi.2010.7.4.251
Shows that histone acetylation mechanisms actively regulate BDNF transcription in the rat hippocampus in response to neuronal stimuli.
Kw Choi, Miran Yoo, Jin-Hee Han. Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation. 2015. https://doi.org/10.1038/emm.2014.129
Highlights chromatin remodeling-dependent control of gene expression in cognitive mammalian brain functions.
K. U, Lin Gao, Huan Zhang, Zeyuan Ji, Jiacheng Lin, S. Peng, Xiaohu Zhang, Shaolong Xue, Weifeng Qin, Lai Ling Tsang, Yonglun Kong, Yin Xia, P. M. Tang, Tao Wang, Wayne Yw Lee, Gang Li, X. Jiang. KDM3A controls postnatal hippocampal neurogenesis via dual regulation of the Wnt/β-catenin signaling pathway. 2025. https://doi.org/10.1038/s41418-025-01470-2
Identifies H3K9 demethylase KDM3A as a key epigenetic regulator of postnatal neurogenesis and memory in the mouse hippocampus.
Isabella Tarulli, Rebecca Toscano-Rivalta, Lisa Watt, Johannes Gräff. Writing the Engram: Epigenetic Mechanisms of Memory Allocation. 2025. https://doi.org/10.1111/jnc.70328
Reviews how epigenetic mechanisms and transcriptional priming shape mammalian neuronal engram allocation.
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