Epigenetic memory mechanisms are actively expressed in mammalian neurons
the verdict
SUPPORTED
the evidence backs this
confidence 89/100
Multiple peer-reviewed studies establish that epigenetic memory mechanisms, such as DNA methylation, histone modification, and chromatin remodeling, are actively expressed and function in mammalian neurons to regulate synaptic plasticity and memory formation.
Evidence for · 5
Loss of Activity-Induced Phosphorylation of MeCP2 Enhances Synaptogenesis, LTP, and Spatial Memory
2011 · cited by 159
Demonstrates that DNA methylation-dependent epigenetic mechanisms and MeCP2 phosphorylation regulate mammalian neuronal function and memory.
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More for · 4
Epigenetic Regulation of BDNF Gene in Response to Stress
2010 · cited by 107
Shows that histone acetylation mechanisms actively regulate BDNF transcription in the rat hippocampus in response to neuronal stimuli.
Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation
2015 · cited by 21
Highlights chromatin remodeling-dependent control of gene expression in cognitive mammalian brain functions.
KDM3A controls postnatal hippocampal neurogenesis via dual regulation of the Wnt/β-catenin signaling pathway
2025 · cited by 9
Identifies H3K9 demethylase KDM3A as a key epigenetic regulator of postnatal neurogenesis and memory in the mouse hippocampus.
Writing the Engram: Epigenetic Mechanisms of Memory Allocation
2025 · cited by 1
Reviews how epigenetic mechanisms and transcriptional priming shape mammalian neuronal engram allocation.