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the claim

Enzymes catalyze reactions favorably in only one physiological direction

the verdict

REFUTED

the evidence says no

confidence 13/100

Enzymes do not strictly catalyze reactions favorably in only one physiological direction; many metabolic enzymes are reversible and their reaction direction depends on cellular thermodynamics and metabolite concentrations.

Evidence against · 2

Thermodynamics shape the <i>in vivo</i> enzyme burden of glycolytic pathways

2025 · cited by 2

Demonstrates that metabolic pathways can operate reversibly depending on thermodynamic driving forces and cellular context.

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More against · 1

Photocontrol of Itaconic Acid Synthesis in Escherichia coli.

2022 · cited by 0

Shows that enzymes such as isocitrate dehydrogenase operate bidirectionally within metabolic cycles like the TCA cycle.

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first checked31 Jul 2026

judged → REFUTED · 1331 Jul 2026

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