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the claim
Enzymes catalyze reactions favorably in only one physiological direction
the verdict
REFUTED
the evidence says no
refutedsupported
the weight of evidence
0 sources for · 2 against

Enzymes do not strictly catalyze reactions favorably in only one physiological direction; many metabolic enzymes are reversible and their reaction direction depends on cellular thermodynamics and metabolite concentrations.

Evidence against · 2
Thermodynamics shape the <i>in vivo</i> enzyme burden of glycolytic pathways
2025 · cited by 2
Demonstrates that metabolic pathways can operate reversibly depending on thermodynamic driving forces and cellular context.
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The analysis

The claim states that enzymes catalyze reactions favorably in only one physiological direction. However, biochemical principles and literature on metabolic pathways show that many enzymatic reactions are reversible and operate in different directions depending on cellular thermodynamics, flux requirements, and metabolite concentrations. Papers 4 and 8 demonstrate the reversibility and bidirectional operation of metabolic pathways and enzymes.

More against · 1
Photocontrol of Itaconic Acid Synthesis in Escherichia coli.
2022 · cited by 0
Shows that enzymes such as isocitrate dehydrogenase operate bidirectionally within metabolic cycles like the TCA cycle.
The paper trail · every fact has a biography
first checked31 Jul 2026
judged → REFUTED · 1331 Jul 2026
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