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the claim
Electric shocks trigger muscle contraction via membrane depolarization
the verdict
COMMON KNOWLEDGE
no citation needed for this one
refutedsupported
the weight of evidence
6 sources for · 0 against

The claim that electric shocks and membrane depolarization trigger muscle contraction is a well-established physiological fact governed by excitation-contraction coupling, where electrical excitation leads to calcium release and mechanical force generation. Therefore, no formal citation is strictly needed, though extensive literature confirms the mechanism.

Evidence for · 6
2003 · cited by 260
Demonstrates that membrane depolarization (via KCl) induces vascular smooth muscle contraction through calcium-dependent mechanisms.
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The analysis

The claim states a fundamental physiological principle of excitation-contraction coupling: electrical stimulation or membrane depolarization causes muscle contraction via calcium signaling and membrane potential changes. This is a matter of established scientific textbook knowledge and everyday observation in physiology. Numerous retrieved papers (such as [1], [2], [4], [5]) discuss excitation-contraction coupling in detail, confirming the causal chain from membrane excitation to calcium-mediated contraction. Because it is a universally accepted physiological fact, the verdict is COMMON_KNOWLEDGE, with supportive papers correctly mapped to for_indices.

More for · 5
2022 · cited by 22
Explains excitation-contraction coupling in skeletal muscle where membrane excitation and action potentials lead to Ca2+-mediated mechanical contraction.
2022 · cited by 14
Examines how skeletal muscle resting potential depolarization links to excitation-contraction coupling and calcium transients responsible for force generation.
2022 · cited by 3
Discusses excitation-contraction coupling where electrical signals originating from the nervous system are converted into muscle contraction via channel cooperation.
2026 · cited by 2
Summarizes excitation-contraction coupling as the mechanism that translates action potentials into calcium release and muscle fiber contraction.
2022 · cited by 1
Integrates physiological models of action potential propagation and calcium handling during skeletal muscle contraction.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. Ca <sup>2+</sup> -Dependent Activation of Rho and Rho Kinase in Membrane Depolarization–Induced and Receptor Stimulation–Induced Vascular Smooth Muscle Contractionpeer-reviewedsupports
  2. Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade researchpeer-reviewedsupports
  3. The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal musclepeer-reviewedsupports
  4. An Electrical Stimulation Method to Control Deep Muscle Contraction using Surface Electrodespeer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Molecular interactions of STAC proteins with skeletal muscle dihydropyridine receptor and excitation‐contraction couplingpeer-reviewedsupports
  6. Exercise Protects Skeletal Muscle Fibers from Age-Related Dysfunctional Remodeling of Mitochondrial Network and Sarcotubular System.peer-reviewedsupports
  7. Structural and Functional Regulation of RyR2 in Cardiac Calcium Handling and Arrhythmogenesis.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Computational Model of the Effect of Mitochondrial Dysfunction on Excitation–Contraction Coupling in Skeletal Musclepeer-reviewedsupports
  9. Optical Mapping of Pacing-Elicited Slow Waves in the Swine Stomach: Role of Virtual Electrodes.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Modulation of satellite cell function to alleviate age-related sarcopenia: Electrical stimulation &amp; Ca²⁺ signaling combined approach.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Electroactive Biomaterials for Cardiovascular Tissue Engineering: Mechanisms, Design Strategies, and Therapeutic Applications.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. The neuromuscular junction: a critical component of functional recovery after peripheral nerve injury.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → COMMON KNOWLEDGE · 9006 Aug 2026
held for human review07 Aug 2026
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