Double-stranded RNA exists naturally within eukaryotic cells
the verdict
SUPPORTED
the evidence backs this
confidence 86/100
Multiple peer-reviewed studies confirm that double-stranded RNA exists naturally inside eukaryotic cells, originating from sources such as repetitive genomic elements, retrotransposons, and mitochondrial transcription.
Evidence for · 4
Endogenous Double-Stranded RNA
2021 · cited by 63
Paper 3 discusses how endogenous double-stranded RNA, arising from repetitive elements and retroviruses, naturally exists and is sequestered within eukaryotic cells.
See more details
More for · 3
Endogenous double-stranded Alu RNA elements stimulate IFN-responses in relapsing remitting multiple sclerosis
2019 · cited by 35
Paper 4 identifies endogenous double-stranded Alu RNA elements transcribed from human leukocyte enhancers.
Diminished SUV3 expression and its functional implications in the IFN-enriched monocyte subset of childhood Sjögren's Disease.
2025 · cited by 3
Paper 7 describes the accumulation of mitochondrial double-stranded RNAs within eukaryotic cells due to bidirectional transcription and homeostatic decay processes.
PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs.
2018 · cited by 0
Paper 10 demonstrates that endogenous noncoding RNAs and mitochondrial RNAs form intermolecular double-stranded RNAs within normal eukaryotic cells.