Dopamine dysregulation syndrome occurs in non-Parkinson's subjects
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Peer-reviewed literature specifically investigates and identifies cases of dopamine dysregulation syndrome occurring in non-Parkinson's disease patients receiving dopamine replacement therapy.
Objectives: To explore the presence of dopamine dysregulation syndrome in non-Parkinson’s disease patients receiving dopamine replacement therapy. Methods: Electronic searches were conducted of Medline, Embase, PsycINFO and PreMedline to capture articles related to dopamine misuse or factitious disorder combined with the presence of dopamine replacement therapy or a non-Parkinson’s disease population. In total, 430 articles were reviewed and studies that addressed dopamine dysregulation syndrome in non-Parkinson’s disease patients were included. Results: Nine case reports were identified. Conclusions: The pathophysiology underlying dopamine dysregulation syndrome has been thoroughly explored with numerous mechanisms posited. What remains unclear is whether dopamine dysregulation syndrome is a phenomenon specific to Parkinson’s disease, as indicated in the proposed diagnostic criteria. A more useful predictor of susceptibility to dopamine dysregulation syndrome may be temperamental traits such as novelty seeking and impulsivity, which overlap with predisposing factors for an addiction disorder.
Dopamine dysregulation syndrome (DDS) is a rare dysfunction of the reward system observed in some individuals taking dopaminergic medications for an extended
Dopamine dysregulation syndrome (DDS) is a rare dysfunction of the reward system observed in some individuals taking dopaminergic medications for an extended length of time. It is characterized by severely disinhibited patterns of behavior, leading to problems such as addiction to the offending medication, compulsive gambling, or compulsive sexual behavior. It typically occurs in people with Parki
Dopamine dysregulation syndrome (DDS) is a rare dysfunction of the reward system observed in some individuals taking dopaminergic medications for an extended length of time. It is characterized by severely disinhibited patterns of behavior, leading to problems such as addiction to the offending medication, compulsive gambling, or compulsive sexual behavior. It typically occurs in people with Parkinson's disease (PD) or restless legs syndrome (RLS) who have taken dopamine agonist medications for an extended period of time.
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