DNA replication requires RNA primers while transcription does not
the verdict
SUPPORTED
the evidence backs this
confidence 86/100
DNA replication strictly requires RNA primers to provide a free 3'-OH group for chain elongation, whereas RNA polymerases (transcription) are capable of initiating de novo synthesis without a primer.
Evidence for · 2
Two modes of transcription initiation in vitro at the rrnB P1 promoter of Escherichia coli.
1993 · cited by 63
Discusses transcription initiation using RNA oligomers synthesized in situ or starting de novo, highlighting the absence of a traditional exogenous primer requirement.
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More for · 1
Binding of the Priming Nucleotide in the Initiation of Transcription by T7 RNA Polymerase*
2003 · cited by 53
Explicitly states that RNA polymerases must initiate transcription de novo without the benefit of an associated primer, unlike DNA polymerases.