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the claim
Different enzymes catalyze the same reaction in opposite directions
the verdict
COMMON KNOWLEDGE
no citation needed for this one
refutedsupported
the weight of evidence
no sources on either side

Enzyme-catalyzed reactions are reversible by the laws of thermodynamics, meaning the same enzyme can catalyze a reaction in either direction depending on substrate and product concentrations.

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The analysis

The claim is a fundamental, textbook principle of enzyme kinetics and chemical thermodynamics (microscopic reversibility). It is common knowledge in biochemistry that enzymes accelerate reactions in both the forward and reverse directions.

Everything we examined (12)
  1. Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Nitrate-Nitrite Interplay in the Nitrogen Biocycle.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. Length distribution of polyelectrolyte chains in reversible thermodynamic equilibriumpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. From flux analysis to self contained cellular models.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Stimuli-Responsive Chemical Systems That Mimic Biological Dynamics.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Are all chemical reactions in principle reversible? Thermodynamic distinction between “conceptually complete” and “practically complete” reactionspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Interpreting terminal selectivity in undirected C(sp<sup>3</sup>)-H functionalization: kinetic insights and mechanistic implications.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Enhancing Diastereoselectivity of l‑Threonine Aldolase by Strengthening Kinetic Control To Mitigate Thermodynamic Equilibrium.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. EHMN 2026: A Thermodynamically Refined, SBML-Standardised Human Metabolic Network for Genome-Scale Analysis and QSP Integration.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Enzymatic oxygen reduction dominates overpotential-driven thermogenesis in mitochondria.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Manipulating Terminal Iron-Hydroxide Nucleophilicity through Redox.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Non-enzymatic error correction in self-replicators without extraneous energy supply.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → COMMON KNOWLEDGE · 9505 Aug 2026
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