While regular soda contributes heavily to obesity and diabetes through excess calories, emerging research shows that diet soda and artificial sweeteners are not entirely inert and may carry independent metabolic risks, leading to ongoing scientific debate.
Evidence for · 8
Artificial food additives: hazardous to long-term health?
2024 · cited by 59
High intake of non-caloric sweeteners has been linked to cardiovascular disease, depression, and metabolic risks.
Evidence against · 4
Stevia rebaudiana Bertoni and Its Effects in Human Disease: Emphasizing Its Role in Inflammation, Atherosclerosis and Metabolic Syndrome
2018 · cited by 40
Stevia consumption has shown general safety and promising potential benefits against inflammation, atherosclerosis, and glucose control.
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More for · 7
Interactions of Non-Nutritive Artificial Sweeteners with the Microbiome in Metabolic Syndrome
2022 · cited by 16
Artificial sweeteners can alter the gut microbiome and potentially promote metabolic derangements.
Artificial and Natural Sweeteners Biased T1R2/T1R3 Taste Receptors Transactivate Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition of Metastatic Phenotype
2024 · cited by 12
Non-nutritive sweeteners are associated with increased risk factors for metabolic syndrome and cellular changes.
Effects of artificial and natural sweeteners on host metabolic health: A double-edged sword.
2025 · cited by 6
Emerging evidence suggests non-sugar sweeteners may be associated with adverse metabolic consequences.
Childhood Obesity and Its Physiological Association with Sugar-Sweetened, Free-Sugar Juice, and Artificially Sweetened Beverages
2025 · cited by 3
Artificially sweetened beverages pose emerging metabolic risks such as gut microbiota disruption and altered appetite regulation.
Sweeteners and Sugar- Their Impact on Human Metabolic Health and Chronic Diseases
2024 · cited by 2
Artificial sweeteners carry potential health risks such as metabolic disturbances despite offering low-calorie alternatives.
The impact of artificial sweeteners on the metabolic syndrome
2024 · cited by 2
Studies indicate negative impacts of artificial sweeteners on obesity, glucose intolerance, dyslipidemia, and blood pressure.
THE IMPACT OF ARTIFICIAL SWEETENERS ON INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS): A LITERATURE REVIEW
2025 · cited by 0
Certain artificial sweeteners may influence insulin secretion and gut microbiota, potentially worsening metabolic outcomes.
More against · 3
Targeting Overconsumption of Sugar-Sweetened Beverages vs. Overall Poor Diet Quality for Cardiometabolic Diseases Risk Prevention: Place Your Bets!
2017 · cited by 33
Sugar-sweetened beverages are frequently highlighted as the primary driver of cardiometabolic risk compared to overall diet quality or substitutes.
Research Progress on the Relationship Between Artificial Sweeteners and Breast Cancer
2024 · cited by 6
Results of studies on artificial sweeteners and breast cancer risk are conflicting, with some failing to confirm a positive correlation.
Knowledge, attitude, and practice of medical students on artificial sweeteners: A cross-sectional study at Medical College and Hospital, Kolkata
2024 · cited by 1
While medical students recognize the caloric advantage of artificial sweeteners for weight reduction, opinions and evidence on long-term effects vary.