Peptic ulcer disease remains a prevalent gastrointestinal disorder worldwide. Current treatments often have limitations, sparking interest in alternative therapies from medicinal plants. This review examines the gastroprotective potential of 54 North African medicinal plants against peptic ulcers. An extensive literature search was conducted, focusing on plants with preclinical and clinical evidence of anti-ulcer efficacy and documented use in North African traditional medicine. The review identified several promising plant species, such as licorice (<i>Glycyrrhiza glabra</i>), chamomile (<i>Matricaria chamomilla</i>), olive (<i>Olea europaea</i>), pomegranate (<i>Punica granatum</i>), Aloe vera, and black seed (<i>Nigella sativa</i>), along with their bioactive constituents, including flavonoids, tannins, and terpenoids. These compounds exhibit gastroprotective properties through multiple mechanisms, such as enhancing the gastric mucosal barrier, inhibiting acid secretion, displaying antioxidant and anti-inflammatory effects, promoting ulcer healing, and combating <i>Helicobacter pylori</i> infection. The evidence presented includes in vitro assays, animal models, and some clinical studies. While many of the 53 plants reviewed demonstrated significant anti-ulcer effects compared to standard drugs, further clinical research is needed to establish efficacy and safety in humans. The synergistic actions of phytochemical mixtures in medicinal plant extracts likely contribute to their therapeutic potential. This review highlights the role these North African medicinal plants may play in the prevention and treatment of peptic ulcers and identifies promising candidates for further research and development of evidence-based botanical therapies. Medicinal Plants for Peptic Ulcer Disease 4.1.1. Abelmoschus esculentus A. esculentus , commonly known as okra or lady's finger. A. esculentus has been traditionally used in certain herbal medicine systems for gastrointestinal health (Ortaç et al. 2018 ). A. esculentus contains mucilage, a gel‐like substance that is known for its demulcent properties. Mucilage can form a protective layer over the gastric mucosa, helping to soothe irritation and inflammation in the stomach lining (Naim et al. 2015 ). Additionally, several studies illustrated Okra is rich in antioxidants, including flavonoids, polyphenols, and vitamin C, which can help neutralize harmful free radicals in the body (Joshi et al. Those compounds are well known for their antioxidant properties, anti‐ulceration, anti‐inflammation (Boutemak, Safta, and Ayachi 2015 ), and anticancer activities (Es‐Safi et al. 2006 ). These findings suggest that G. alypum has the potential to offer gastroprotective benefits, making it a promising candidate for further exploration in gastroprotection research. Nevertheless, further research, including preclinical and clinical studies, is needed to elucidate its efficacy and safety for the prevention and treatment of peptic ulcers and other gastrointestinal disorders. 4.1.21. Glycyrrhiza glabra Licorice derived from the roots of G. Lavender has been traditionally used for its calming and stress‐relieving properties. By reducing stress and anxiety levels, lavender may indirectly help prevent ulcers and promote gastrointestinal health (Javed et al. 2020 ). 4.1.28. Lawsonia inermis L. L. inermis , commonly known as henna, exhibits therapeutic effects on gastric ulcers. Studies have shown that L. inermis possesses anti‐ulcer properties (Elansary et al. 2020 ; Moutawalli et al. 2023 ). Additionally, purslane contains omega‐3 fatty acids, flavonoids, and polysaccharides, which have demonstrated anti‐inflammatory properties. Chronic inflammation is a contributing factor to the development and progression of gastric ulcers. By reducing inflammation in the stomach lining, purslane may aid in the healing process of gastric ulcers (Kumar et al. 2010 ). 4.1.45. Punica granatum Studies have explored the potential of P. granatum , or pomegranate, in treating and preventing stomach ulcers due to its traditional medicinal use and perceived health benefits. It is believed that P. These compounds may help reduce inflammation in the gastrointestinal tract and protect the gastric mucosa from damage. Further, Ziziphus species contain antioxidants that help scavenge free radicals and reduce oxidative stress. By protecting against oxidative damage, these antioxidants may contribute to the maintenance of gastric health and the prevention of gastric ulcers. Research indicates that Ziziphus extracts may exhibit anti‐ulcer activity by reducing gastric acid secretion, inhibiting the activity of enzymes involved in ulcer formation, and promoting the healing of gastric ulcers. Overall, plant‐derived compounds like EGCG play a crucial role in facilitating gastric mucosal healing by promoting epithelial cell proliferation, fostering angiogenesis, and mitigating inflammation and oxidative stress. By accelerating ulcer healing and restoring the structural integrity of the gastric mucosa, these compounds offer promising therapeutic benefits in the management of peptic ulcers, reducing the likelihood of ulcer recurrence and improving clinical outcomes for affected individuals (Rodríguez‐Negrete et al. 2024 ). 5.6. By modulating the activity of these proton pumps, DGL effectively reduces the production of gastric acid, leading to decreased acidity within the stomach. The reduction in gastric acid secretion achieved by DGL offers several benefits in the management of peptic ulcers. Firstly, it helps alleviate symptoms such as abdominal pain, heartburn, and indigestion, which are often exacerbated by excessive gastric acid secretion. By lowering acid levels, DGL provides symptomatic relief, improving the overall quality of life for individuals with peptic ulcers. Moreover, the reduction in gastric acid secretion creates a more favorable environment for mucosal healing.