COVID-19 testing capacity can be amplified by pooling multiple samples together
Multiple studies demonstrate that pooling multiple clinical samples together for COVID-19 testing can dramatically increase throughput, conserve testing resources, and amplify overall screening capacity.
The claim is specific and empirical. Numerous published studies evaluate group and pooled testing strategies for SARS-CoV-2, showing significant gains in testing efficiency and throughput without compromising overall diagnostic utility, leading to a SUPPORTED verdict.
C. M. Verdun, Tim Fuchs, P. Harár, Dennis Elbrächter, David S. Fischer, Julius Berner, P. Grohs, F. Theis, Felix Krahmer. Group Testing for SARS-CoV-2 Allows for Up to 10-Fold Efficiency Increase Across Realistic Scenarios and Testing Strategies. 2020. https://doi.org/10.3389/fpubh.2021.583377
Demonstrates that group testing strategies can increase testing efficiency up to 10-fold across realistic COVID-19 scenarios.
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Rodrigo Noriega, Matthew H. Samore. Increasing testing throughput and case detection with a pooled-sample Bayesian approach in the context of COVID-19. 2020. https://doi.org/10.1101/2020.04.03.024216
Shows that pooled-sample protocols can significantly increase throughput and detection efficiency despite moderate sensitivity losses.
De Zhou, Man Zhou. Mathematical Model and Optimization Methods of Wide-Scale Pooled Sample Testing for COVID-19. 2022. https://doi.org/10.3390/math10071183
Details large-scale pooled nucleic acid testing methods used in cities like Wuhan and Qingdao to rapidly suppress outbreaks.
Syed Usama Khalid Bukhari, Syed Safwan Khalid, Asmara Syed, Syed Sajid Hussain Shah. Smart Pooled sample Testing for COVID-19: A Possible Solution for Sparsity of Test Kits. 2020. https://doi.org/10.1101/2020.04.21.20044594
Explains how smart pooled sample testing algorithms can help overcome shortages of test kits during exponential spread.
Bethany Hyde, Prat Verma, Ethan M. Berke. Pooled Sample Testing for SARS-CoV-2 Using Rapid RT-PCR COVID-19 Tests. 2021. https://doi.org/10.1101/2021.01.22.21250339
Confirms that pooling samples on rapid PCR devices maintains performance while offering scalable testing at lower cost.
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