Congenital insensitivity to pain was documented and is extremely rare

A. López-Cortés, A. Zambrano, P. Guevara-Ramírez, B. A. Echeverría, Santiago Guerrero, E. Cabascango, A. Pérez-Villa, I. Armendáriz-Castillo, J. García-Cárdenas, V. Yumiceba, G. Pérez-M, P. Leone, C. Paz-y-Miño. Clinical, genomics and networking analyses of a high-altitude native American Ecuadorian patient with congenital insensitivity to pain with anhidrosis: a case report. 2020. https://doi.org/10.1186/s12920-020-00764-3

Notes that CIPA is an extremely rare autosomal recessive disorder characterized by insensitivity to pain.

Liena Gasina, Nityanand Jain, Arturs Viksne, D. Ozols, Mohit Kakar, Uldis Bergmanis. Recurrent Osteomyelitis in a Paediatric Patient with a Novel NTRK1 Mutation: A Case Report on Congenital Insensitivity to Pain with Anhidrosis. 2025. https://doi.org/10.3390/children12030344

Identifies CIPA as an exceedingly rare genetic disorder characterized by the inability to perceive pain.

H. Hamdani, N. Mtalai, Sara Ennaki, G. Daghouj, L. E. Maaloum, B. Allali, A. Kettani, L. E. Maaloum. Congenital Insensitivity TO Pain: A Case Report. 2023. https://doi.org/10.24018/ejmed.2023.5.4.1782

Describes congenital insensitivity to pain as a rare genetic disorder and references historical documentation beginning in the 1930s.

N. Al-Hroub, A. Alsalahat, M. Taamreh, Fawzy M. Abunejma, Osama N. Dukmak. Congenital Insensitivity to Pain: A Case Study of a Rare Genetic Disorder. 2024. https://doi.org/10.7759/cureus.69414

Classifies congenital insensitivity to pain as an exceedingly rare autosomal recessive condition.

Malek N. Itmaiza, Adriana J. Skafi, A. Adawi, Peter R Bael, Nouraldin M M Ibaidi. First instance of pain in congenital pain insensitivity with anhidrosis.. 2025. https://doi.org/10.1016/j.clineuro.2025.108775

Describes a case of a patient known to have congenital insensitivity to pain and notes the syndrome's rarity.

Xiong Q, Huang L, Hu Y, Fu W. Case Report: Arthroscopic synovectomy and loose body removal for charcot knee in an adolescent with congenital insensitivity to pain with anhidrosis.. 2026. https://doi.org/10.3389/fsurg.2026.1767073

Notes that Charcot neuroarthropathy in adolescents with congenital insensitivity to pain with anhidrosis is exceptionally rare.

Temur KT. Uncovering oral and maxillofacial clues in congenital insensitivity to pain with anhidrosis: what can sibling cases teach us?. 2025. https://doi.org/10.1186/s12903-025-07202-9

Describes CIPA as an extremely congenital disorder characterized by severe clinical manifestations including pain insensitivity.

Karabinos A, Tomkova E, Sprincova A, Tothova K, Repiska V, Jesenak M, Krizan P. A Novel Inflammatory Autoimmune-Like <i>NTRK1</i>-Associated Phenotype in an Adult Man.. 2025. https://doi.org/10.1159/000549961

Notes that CIPA is a rare autosomal recessive disorder characterized by congenital analgesia.

Abdel-Bari ABAT, Fawzy M, Saad KA, Alhadainy HA. Multidisciplinary Approach for Dental Management of Congenital Insensitivity to Pain with Anhidrosis: Clinical Case Report with 12-Month Follow-Up.. 2026. https://doi.org/10.3390/dj14010068

States that congenital insensitivity to pain and anhidrosis is a rare autosomal recessive disorder.

Lala S, Almustafa A. Oral Rehabilitation in Patient With Hereditary Sensory and Autonomic Neuropathy (HSAN) Type V: Clinical Report.. 2025. https://doi.org/10.1155/crid/6868923