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the claim
Compounds can be soluble in solvent mixtures while insoluble in the individual pure solvents
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
7 sources for · 0 against

Compounds frequently exhibit a strong cosolvency effect, displaying significantly higher solubility in specific solvent mixtures than in any of the individual pure components alone.

Evidence for · 7
Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures
2008 · cited by 663
Reviews how cosolvency models predict enhanced solubility in solvent mixtures compared to individual solvents.
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The analysis

The retrieved literature extensively covers cosolvency, demonstrating that many compounds have a solubility peak in binary or ternary solvent mixtures that far exceeds their solubility in the respective pure individual solvents.

More for · 6
Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures
2013 · cited by 250
Examines how binary solvent mixtures like ethanol and propylene glycol alter drug solubility profiles.
Solubility Enhancement of Etoricoxib by Cosolvency Approach
2012 · cited by 112
Demonstrates the cosolvency approach where solvent blends significantly increase solute solubility.
A Unified Cosolvency Model for Calculating Solute Solubility in Mixed Solvents
2005 · cited by 61
Discusses various linear and non-linear cosolvency models demonstrating enhanced solubilization in mixed solvents.
The solubility profile and dissolution thermodynamic properties of minocycline hydrochloride in some pure and mixed solvents at several temperatures
2021 · cited by 29
Reports that minocycline hydrochloride solubility increases dramatically in solvent mixtures compared to individual pure solvents.
Cosolvent effect on solubility of aripiprazole in mixed solvents and apparent thermodynamic analysis of dissolution process
2019 · cited by 26
Observes that aripiprazole exhibits a solubility maximum in mixed solvents compared to pure components.
Application of the Solute–Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations
2022 · cited by 18
Shows strong cosolvency effects where binary solvent mixtures yield higher solubility than individual pure components.
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first checked31 Jul 2026
judged → SUPPORTED · 9331 Jul 2026
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