Cold temperatures trigger nociceptors to produce pain sensations
the verdict
SUPPORTED
the evidence backs this
confidence 95/100
Cold temperatures activate specialized peripheral sensory neurons and thermoreceptors (such as TRPM8) that transduce thermal shifts into electrical signals, triggering pain sensations under both normal and pathological conditions.
Evidence for · 4
Nociceptors: the sensors of the pain pathway
2010 · cited by 1,419
Specialized peripheral sensory neurons, known as nociceptors, detect extremes in temperature and pressure to alert the body to potentially damaging stimuli.
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More for · 3
Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
2011 · cited by 353
Oxaliplatin treatment exaggerates cold perception by modifying ion channel expression in cold-sensing peripheral afferents, leading to cold hypersensitivity and pain.
A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia
2013 · cited by 275
Research shows that TRPM8-expressing neurons and channels are required for behavioral responses to both normal cold and noxious, painful cold temperatures.
Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice
2011 · cited by 206
Pharmacological blockade of the cold-sensing TRPM8 channel alters behavioral responses to noxious cold and diminishes injury-evoked cold pain.