Classical conditioning paradigms successfully model hippocampal learning
Multiple studies demonstrate that classical conditioning paradigms, particularly trace conditioning tasks, successfully engage and model hippocampal learning and memory processes.
The retrieved papers provide robust experimental evidence across multiple species and conditioning modalities (such as trace eyeblink and trace fear conditioning) showing that classical conditioning paradigms reliably recruit hippocampal circuits and model hippocampal-dependent learning.
W. Tseng, R. Guan, J.F. Disterhoft, C. Weiss. Trace eyeblink conditioning is hippocampally dependent in mice. 2003. https://doi.org/10.1002/hipo.10157
Demonstrates that trace eyeblink conditioning, a classical conditioning paradigm, is dependent on dorsal hippocampal neurons in mice.
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Miriam S. Nokia, Jan Wikgren. Effects of Hippocampal State-Contingent Trial Presentation on Hippocampus-Dependent Nonspatial Classical Conditioning and Extinction. 2014. https://doi.org/10.1523/jneurosci.4859-13.2014
Shows that hippocampal state and theta oscillations modulate trace eyeblink conditioning and extinction in rabbits.
Kobayashi KS, Sogabe R, Tatsukawa T, Teramae JN, Matsuo N. Neural substrate of conditioned stimulus for associative learning in the hippocampus.. 2026. https://doi.org/10.1073/pnas.2519161123
Identifies hippocampal CA1 engram cells activated during contextual fear conditioning as a neural substrate for conditioned stimuli.
Bassett TE, Wang YZ, Wood EM, Zhang H, Petrovic Z, Prifti V, Jovasevic V, Yamawaki N, Ren L, Khalatyan N, Grayson V, Savas JN, Radulovic J, Cicvaric A. Response dynamics of discrete subiculum→retrosplenial cortex projections underlying trace fear conditioning.. 2026. https://doi.org/10.1016/j.isci.2026.115317
Establishes that subiculum-retrosplenial projections subserve the associative and temporal components of trace fear conditioning.
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