Chronic prostatitis cannot be cured solely with antibiotics
the verdict
INSUFFICIENT LEANING
refutedsupported
the weight of evidence
5 sources for · 0 against
Peer-reviewed studies and systematic reviews indicate that managing chronic prostatitis frequently incorporates alternative or adjunctive treatments such as acupuncture and herbal decoctions alongside standard medical therapy, though direct proof regarding the absolute limitations of monotherapy antibiotics is partially covered.
Acupuncture is a promising therapy for relieving symptoms in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), which affects >15% of adult men worldwide. The aim of the study was to assess the effects and safety of the use of acupuncture for CP/CPPS. MEDLINE, EMBASE, CENTRAL, Web of Science, CBM, CNKI, Wang-Fang Database, JCRM, and CiNii were searched from their inception through 30 November 2015. Grey literature databases and websites were also searched. No language limits were applied. Only randomized controlled trials (RCTs) with CP/CPPS treated by acupuncture were included. Two reviewers extracted data and assessed the risk of bias of RCTs using the Cochrane Risk of Bias Tools, respectively. Seven trials were included, involving 471 participants. The result of meta-analysis indicated that compared with sham acupuncture (MD: -6.09 [95%CI: -8.12 to -5.68]) and medicine (Levofloxacinand, Ibuprofen, and Tamsulosin) (MD: -4.57 [95%CI: -7.58 to -1.56]), acupuncture was more effective at decreasing the total NIH-CPSI score. Real acupuncture was superior to sham acupuncture in improving symptoms (pain, voiding) and quality of life (Qof) domain subscores. Compared to sham acupuncture and medicine, acupuncture appears to be more effective at improving the global assessment. Two trials found that there is no significant difference between acupuncture and sham acupuncture in decreasing the IPSS score. Acupuncture failed to show more favorable effects in improving both symptoms and the Qof domain compared with medicine. Overall, current evidence supports acupuncture as an effective treatment for CP/CPPS-induced symptoms, particularly in relieving pain. Based on the meta-analysis, acupuncture is superior to sham acupuncture in improving symptoms and Qof. Acupuncture might be similar to medicine (Levofloxacinand, Ibuprofen, and Tamsulosin) in its long-term effects, but evidence was limited due to high ROB among included trials as well as potential heterogeneity. Acup
Medicine (Baltimore) Medicine (Baltimore) 2786 medicine MEDI Medicine 0025-7974 1536-5964 Wolters Kluwer Health PMC4839929 PMC4839929.1 4839929 4839929 26986148 10.1097/MD.0000000000003095 1 7300 Research Article Systematic Review and Meta-Analysis Systematic Review of Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome Qin Zongshi MM Wu Jiani MD Zhou Jing MM Liu Zhishun MD Hanaoka. Kazuo From the Department of Acupuncture (ZQ, JW, JZ, ZL), Guang’anmen Hospital, China Academy of Chinese Medical Sciences; and Beijing University of Chinese Medicine (ZQ, JZ), Beijing, China.
pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement yes pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY OPEN-ACCESS TRUE INTRODUCTION Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is 1 of 4 different categories of chronic prostatitis classified by the National Institute of Health (NIH) and is different from the first and second types.
The search terms related to acupuncture, chronic prostatitis, chronic pelvic pain syndrome, and randomized controlled trials. No language barriers were imposed. (See Table 1, Supplemental Content which represents the strategy for searching in the PUBMED database). Study Selection Two reviewers (JW and JZ) scanned the titles and abstracts independently and according to the eligibility assessments, which is protocol for systematic reviews. The search results will be imported to EndNote X7 software (Thomson Reuters, New York, NY) if available. Furthermore, duplications will also be eliminated by EndNote X7 software.
The source of heterogeneity may relate to different follow-up periods and the number of acupoints selected 24 , 27 (Figure 8 ). FIGURE 2 Forest plot of the effect of acupuncture versus sham acupuncture on the NIH-CPSI total score using the random model. NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index. FIGURE 3 Forest plot of the effect of acupuncture versus sham acupuncture on the NIH-CPSI pain domain score using the random model. NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index. FIGURE 4 Forest plot of the effect of acupuncture versus sham acupuncture on the NIH-CPSI voiding domain score using the random model.
NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index. FIGURE 5 Forest plot of the effect of acupuncture versus sham acupuncture on the NIH-CPSI Qof domain score using the random model. NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index, Qof = quality of life. FIGURE 6 Forest plot of the effect of
After combing data, the result indicated that patients treated with medication failed to report an improvement in their symptoms more frequently than patients treated with acupuncture (RR: 1.43 [95%CI: 1.08–1.90]) with moderate heterogeneity ( I 2 = 51%) 22 , 25 (Figure 13 ). FIGURE 9 Forest plot of the effect of acupuncture versus medication on the NIH-CPSI total score. NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index. FIGURE 10 Forest plot of the effect of acupuncture versus medication on the NIH-CPSI pain domain score. NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index.
FIGURE 11 Forest plot of the effect of acupuncture versus medication on the NIH-CPSI voiding domain score. NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index. FIGURE 12 Forest plot of the effect of acupuncture versus medication on the NIH-CPSI Qof domain score. NIH-CPSI = National Institute of Health Chronic Prostatitis Symptom Index, Qof = quality of life. FIGURE 13 Forest plot of the effect of acupuncture versus medication on the global assessment.
Abstract Alpha-blockers and antibiotics are most commonly used to treat chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in clinical practice. Currently, increasing evidence also suggests acupuncture as an effective strategy. This network meta-analysis intended to assess the comparative efficacy and safety of acupuncture, alpha-blockers and antibiotics for CP/CPPS. Twelve trials involving 1203 participants were included. Based on decreases in the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score, a network meta-analysis indicated that electro-acupuncture (standard mean difference [SMD]: 4.29; 95% credible interval [CrI], 1.96–6.65), acupuncture (SMD: 3.69; 95% CrI, 0.27–7.17), alpha-blockers (SMD: 1.85; 95% CrI, 1.07–2.64), antibiotics (SMD: 2.66; 95% CrI, 1.57–3.76), and dual therapy (SMD: 3.20; 95% CrI, 1.95–4.42) are superior to placebo in decreasing this score. Additionally, electro-acupuncture (SMD: 2.44; 95% CrI, 0.08–4.83) and dual therapy (SMD: 1.35; 95% CrI, 0.07–2.62) were more effective than alpha-blockers in decreasing the total NIH-CPSI total score. Other network meta-analyses did not show significant differences between interventions other placebo. The incidence of adverse events of acupuncture was relatively rare (5.4%) compared with placebo (17.1%), alpha-blockers (24.9%), antibiotics (31%) and dual therapy (48.6%). Overall, rank tests and safety analyses indicate that electro-acupuncture/acupuncture may be recommended for the treatment of CP/CPPS.
Sci Rep Sci Rep 1579 scirep Scientific Reports 2045-2322 Nature Publishing Group PMC5069632 PMC5069632.1 5069632 5069632 27759111 10.1038/srep35737 srep35737 1 Article Network Meta-Analysis of the Efficacy of Acupuncture, Alpha-blockers and Antibiotics on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Qin Zongshi 1 2 * Wu Jiani 1 * Tian Jinhui 3 Zhou Jing 1 Liu Yali 3 4 Liu Zhishun a 1 1 Department of Acupuncture, Guang’anmen Hospital, China Academy of Chinese Medical Sciences , Beijing, China 2 Beijing University of Chinese Medicine , Beijing, China 3 Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University , Lanzhou, China 4 Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medicine Sciences , Beijing, China a liuzhishun@aliyun.com * These authors contributed equally to this work.
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ Alpha-blockers and antibiotics are most commonly used to treat chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in clinical practice. Currently, increasing evidence also suggests acupuncture as an effective strategy. This network meta-analysis intended to assess the comparative efficacy and safety of acupuncture, alpha-blockers and antibiotics for CP/CPPS. Twelve trials involving 1203 participants were included.
Based on decreases in the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score, a network meta-analysis indicated that electro-acupuncture (standard mean difference [SMD]: 4.29; 95% credible interval [CrI], 1.96–6.65), acupuncture (SMD: 3.69; 95% CrI, 0.27–7.17), alpha-blockers (SMD: 1.85; 95% CrI, 1.07–2.64), antibiotics (SMD: 2.66; 95% CrI, 1.57–3.76), and dual therapy (SMD: 3.20; 95% CrI, 1.95–4.42) are superior to placebo in decreasing this score. Additionally, electro-acupuncture (SMD: 2.44; 95% CrI, 0.08–4.83) and dual therapy (SMD: 1.35; 95% CrI, 0.07–2.62) were more effective than alpha-blockers in decreasing the total NIH-CPSI total score.
Thus, prostatitis places a significant economic burden on both individuals and society attributed by causing productivity absenteeism and incurring health care cost 3 . At present, a gold standard diagnostic test for CP/CPPS is not available
In addition, adverse events due to the treatments were recorded. Data Sources and Searches We performed electronic searches of following databases: Embase, PubMed, and the Cochrane Library. The search strategy consisted of three parts and included CP/CPPS (participants), alpha-blockers, antibiotics, acupuncture (interventions and controls), and a specific filter for randomized controlled trials (studies). The following keywords were used in combination with both MeSH terms and text words: chronic prostatitis, chronic pelvic pain, nonbacterial prostatitis, acupuncture, alpha blocker, alpha adrenergic receptor blocker, alpha adrenergic receptor antagonist, antibiotic, and antibacterial.
Network Meta-Analysis of the Efficacy of Acupuncture, Alpha-blockers and Antibiotics on Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Sci. Rep. 6 , 35737; doi: 10.1038/srep35737 (2016). Supplementary Material Supplementary Information Figure 1 PRISMA flow chart Figure 2 Network plot. Figure 3 SUCRA for NIH-CPSI total score. Figure 4 SUCRA for NIH-CPSI pain score. Figure 5 SUCRA for NIH-CPSI voiding score. Figure 6 SUCRA for NIH-CPSI QoL score. Table 1 Characteristics of Included Studies.
Table 3 Results of National Institutes of Health Chronic Prostatitis Symptom Index Total Score.
NA: not available. Results of direct and indirect comparisons in the total National Institutes of Health Chronic Prostatitis Symptom Index score. Table 4 Results of National Institutes of Health Chronic Prostatitis Symptom Index Pain Score.
NA: not available. Results of direct and indirect comparisons in National Institutes of Health Chronic Prostatitis Symptom Index pain score. Table 5 Results of National Institutes of Health Chronic Prostatitis Symptom Index Voiding Score.
NA: not available. Results of direct and indirect comparisons in National Institutes of Health Chronic Prostatitis Symptom Index voiding score. Table 6 Results of National Institutes of Health Chronic Prostatitis Symptom Index Quality of Life Score.
NA: not available. Results of direct and indirect comparisons in National Institutes of Health Chronic Prostatitis Symptom Index quality of life score.
<h4>Background</h4>Traditional Chinese medicine (TCM) posits that chronic prostatitis is associated with the accumulation of damp-heat pathogenic factors in the lower jiao. The Bixie Fenqing decoction (BFD) eliminates damp-heat pathogenic factors in the body, thereby alleviating inflammation and improving symptoms.<h4>Methods</h4>Databases such as CNKI, WanFang, VIP, CBM, ClinicalKey, PubMed, Embase, and the Cochrane Library were searched. The search time ranged from the establishment of the database until March 30, 2024. RCTs that used BFD for chronic prostatitis were screened. The methodological quality of the studies was evaluated using the Cochrane Scoring System. Meta-analysis of outcome indicators was performed using RevMan 5.4 software, and Egger analysis of publication bias for the primary outcome indicators was conducted using Stata 16 software.<h4>Results</h4>This analysis included 1104 patients. Meta-analysis showed that BFD significantly improved clinical efficacy in patients with chronic prostatitis, with a total effective rate (RR = 1.20, 95% CI: 1.13 to 1.26, P < .00001) and cure rate (RR = 1.52, 95% CI: 1.24 to 1.86, P < .00001). It significantly reduced the NIH-CPSI (National Institutes of Health-Chronic Prostatitis Symptom Index) scores, levels of inflammatory factors, white blood cell counts, and TCM syndrome scores in patients with chronic prostatitis. Specifically, the NIH-CPSI total scores (MD = -4.41, 95% CI: -5.27 to -3.55, P < .00001), NIH-CPSI pain scores (MD = -2.08, 95% CI: -2.93 to -1.23, P < .00001), NIH-CPSI urinary symptom scores (MD = -1.13, 95% CI: -1.69 to -0.57, P < .0001), NIH-CPSI quality of life scores (MD = -1.25, 95% CI: -1.76 to -0.75, P < .00001), levels of inflammatory factors TNF-α (MD = -11.18, 95% CI: -13.84 to -8.53, P < .00001) and IL-10 (MD = -20.60, 95% CI: -26.82 to -14.37, P < .00001) in prostatic fluid, white blood cell counts in prostatic fluid (MD = -2.91, 95% CI: -5.46 to -0.36, P = .03), and TCM syndrome scores (MD = -7.01, 95% CI: -8.13 to -5.90, P < .00001) were all significantly improved.<h4>Conclusion</h4>BFD has a definite effect on the treatment of chronic prostatitis.
Therapeutic Effects of Lycopene Alone or in Combination with Cephalexin on Chronic Prostatitis Caused by Staphylococcus aureus in a Rat Model - Archive ouverte HAL × × × Loading...
× Article Dans Une Revue Microbiology Research Année : 2025 Therapeutic Effects of Lycopene Alone or in Combination with Cephalexin on Chronic Prostatitis Caused by Staphylococcus aureus in a Rat Model Soumia Keddari (1) , Djahira Hamed (1, 2) , Abla Bouhend (1) , Mokhtaria Yasmina Boufadi (1) , Meriem Mokhtar (1) , Bouasria Benbouziane (1) , Nabil Touzout (3) , Sabrina Lekmine (4) , Jie Zhang , Abdeltif Amrane (5, 6) , Hichem Tahraoui (3, 5, 6) Afficher plus de détails 1 Université Abdelhamid Ibn Badis de Mostaganem (Monstaganem - Algérie) 301048 "> Université Abdelhamid Ibn Badis de Mostaganem 2 UBBAT - Université Ain Temouchent Belhadj Bouchaib = Ain Temouchent University Belhadj Bouchaib (Route de sidi bel abess, N101, Ain Temouchent 46000, Algérie - Algérie) 1075027 "> UBBAT - Université Ain Temouchent Belhadj Bouchaib = Ain Temouchent University Belhadj Bouchaib 3 YFUM - Yahya Fares University - Medea = Université Yahia Fares de Médéa [Medea, Algeria] (Médéa, Algérie - Algérie) 356141 "> YFUM - Yahya Fares University - Medea = Université Yahia Fares de Médéa [Medea, Algeria] 4 Universite Abbes Laghrour [Khenchela] (BP 1252 Route de Batna Khenchela -40004 - Algérie) 421622 "> Universite Abbes Laghrour [Khenchela] 5 ENSCR - Ecole Nationale Supérieure de Chimie de Rennes (France) 300373 "> ENSCR - Ecole Nationale Supérieure de Chimie de Rennes 6 ISCR - Institut des Sciences Chimiques de Rennes (Campus de Beaulieu - Bât.
10 Avenue du Général Leclerc 35042 Rennes Cedex - France) 194938 UR - Université de Rennes (Campus de Beaulieu, 263 avenue Général Leclerc, CS 74205, 35042 RENNES CEDEX - France) 105160 INSA Rennes - Institut National des Sciences Appliquées - Rennes (20, avenue des Buttes de Coësmes - CS 70839 - 35708 Rennes cedex 7 - France) 117606 INSA - Institut National des Sciences Appliquées (France) 301232 ENSCR - Ecole Nationale Supérieure de Chimie de Rennes (France) 300373 INC-CNRS - Institut de Chimie - CNRS Chimie (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 3 rue Michel-Ange 75794 PARIS CEDEX 16 - France - France) 341038 CNRS - Centre National de la Recherche Scientifique : UMR6226 (France) 441569 "> ISCR - Institut des Sciences Chimiques de Rennes Soumia Keddari Fonction : Auteur PersonId : 1561040 ORCID : 0000-0003-3102-9722 Université Abdelhamid Ibn Badis de Mostaganem Djahira Hamed Fonction : Auteur PersonId : 1561041 ORCID : 0000-0001-8942-7243 Université Abdelhamid Ibn Badis de Mostaganem UBBAT - Université Ain Temouchent Belhadj Bouchaib = Ain Temouchent University Belhadj Bouchaib Abla Bouhend Fonction : Auteur Université Abdelhamid Ibn Badis de Mostaganem Mokhtaria Yasmina Boufadi Fonction : Auteur PersonId : 1561042 ORCID : 0000-0003-2087-4058 Université Abdelhamid Ibn Badis de Mostaganem Meriem Mokhtar Fonction : Auteur PersonId : 1155104 ORCID : 0000-0002-3176-9467 Université Abdelhamid Ibn Badis de Mostaganem Bouasria Benbouziane Fonction : Auteur PersonId : 1561043 ORCID : 0000-0003-1680-9536 Université Abdelhamid Ibn Badis de Mostaganem Nabil Touzout Fonction : Auteur PersonId : 1345661 ORCID : 0000-0002-7091-9990 YFUM - Yahya Fares University - Medea = Université Yahia Fares de Médéa [Medea, Algeria] Sabrina Lekmine Fonction : Auteur PersonId : 1300684 ORCID : 0000-0002-4945-7170 Universite Abbes Laghrour [Khenchela] Jie Zhang Fonction : Auteur PersonId : 1226329 ORCID : 0000-0002-9745-664X Abdeltif Amrane Fonction : Auteur PersonId : 768602 IdHAL : abdeltif-amrane ORCID : 0000-0003-2622-2384 IdRef : 07491412X ENSCR - Ecole Nationale Supérieure de Chimie de Rennes ISCR - Institut des Sciences Chimiques de Rennes Hichem Tahraoui Fonction : Auteur correspondant PersonId : 1223271 Connectez-vous pour contacter l'auteur YFUM - Yahya Fares University - Medea = Université Yahia Fares de Médéa [Medea, Algeria] ENSCR - Ecole Nationale Supérieure de Chimie de Rennes ISCR - Institut des Sciences Chimiques de Rennes Réduire la vue détaillée Résumé en Chronic bacterial prostatitis (CBP) is caused by bacterial infection, commonly treated with fluoroquinolones.
Due to rising antibiotic resistance, alternative therapies such as phytotherapy are being explored. Lycopene, a potential antioxidant with anti-inflammatory properties, is a candidate for such therapy. This study aims to evaluate lycopene’s therapeutic effects alone or with cephalexin against chronic prostate infections induced by Staphylococcus aureus using the Wistar rat model. The CBP model was established by introducing S. aureus through the urethra into the prostatic duct in 25 rats, confirming infection via uriculture and spermoculture analysis.
Therapeutic Effects of Lycopene Alone or in Combination with Cephalexin on Chronic Prostatitis Caused by Staphylococcus aureus in a Rat Model. Microbiology Research , 2025, 16 (6), pp.114. ⟨10.3390/microbiolres16060114⟩ . ⟨hal-05155855⟩ Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Collections UNIV-RENNES1 CNRS INSA-RENNES ISCR SCR-CIP INC-CNRS UR1-UFR-SPM UNIV-RENNES INSA-GROUPE UR1-MMS 105 Consultations 141 Téléchargements Altmetric Partager More
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