Certain viruses are capable of infecting cells across multiple different species
the verdict
SUPPORTED
the evidence backs this
confidence 91/100
Extensive scientific literature demonstrates that various viruses possess the ability to cross species barriers and infect multiple different hosts, often facilitated by genetic mutations or reassortment.
Evidence for · 12
Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus
2008 · cited by 398
Demonstrates that adaptive mutations in influenza A virus proteins enable successful replication and nuclear transport in mammalian cells during interspecies transmission.
See more details
More for · 11
Susceptibility of White-Tailed Deer (Odocoileus virginianus) to SARS-CoV-2
2021 · cited by 226
Shows that SARS-CoV-2 can infect white-tailed deer and transmit between them, illustrating cross-species infection capability.
Influenza type A in humans, mammals and birds: Determinants of virus virulence, host‐range and interspecies transmission
2003 · cited by 165
Discusses how avian influenza viruses can directly transmit to humans and other mammalian hosts, highlighting host-range flexibility.
A unique feature of swine ANP32A provides susceptibility to avian influenza virus infection in pigs
2020 · cited by 53
Identifies specific swine proteins that support avian influenza virus infection, demonstrating interspecies susceptibility in pigs.
Rat hepatitis E virus cross-species infection and transmission in pigs
2024 · cited by 20
Proves that rat hepatitis E virus strains are capable of cross-species infection and transmission in pigs.
Natural reservoir Rousettus aegyptiacus bat host model of orthonairovirus infection identifies potential zoonotic spillover mechanisms
2022 · cited by 17
Reports that Egyptian rousette bats serve as natural reservoir hosts for Kasokero virus with potential for zoonotic spillover.
Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species
2024 · cited by 11
Compares swine enteric coronavirus replication across cells of various species, demonstrating broad cross-species infection potential.
Emerging threats of H5N1 clade 2.3.4.4b: cross-species transmission, pathogenesis, and pandemic risk
2025 · cited by 10
Outlines how H5N1 avian influenza clade 2.3.4.4b crosses species barriers to infect various mammalian species, including cattle and humans.
The basis of mink susceptibility to SARS-CoV-2 infection
2022 · cited by 8
Explains that SARS-CoV-2 spike protein mutations enable successful cross-species infection of minks from humans.
Integrated analysis of miRNA-mRNA expression of newly emerging swine H3N2 influenza virus cross-species infection with tree shrews
2024 · cited by 8
Analyzes the cross-species infection of a swine influenza virus in tree shrews, highlighting viral adaptability across diverse mammalian hosts.
A Review of Cross-Species Transmission Mechanisms of Influenza Viruses
2025 · cited by 6
Reviews the mechanisms by which influenza viruses breach host barriers to achieve cross-species transmission and zoonotic spillover.
Interspecies Transmission of Animal Rotaviruses to Humans: Reassortment-Driven Adaptation
2025 · cited by 4
Examines how rotaviruses traditionally specific to animals can infect humans via genetic reassortment and adaptation.