Certain organic reaction pathways proceed via ambimodal transition states
the verdict
SUPPORTED
the evidence backs this
confidence 83/100
Multiple computational and mechanistic studies confirm that certain organic reaction pathways proceed via ambimodal transition states, which undergo post-transition state bifurcation to yield multiple distinct products.
Evidence for · 6
Computational Exploration of the Mechanism of Critical Steps in the Biomimetic Synthesis of Preuisolactone A, and Discovery of New Ambimodal (5 + 2)/(4 + 2) Cycloadditions.
2021 · cited by 18
Paper [0] identifies an ambimodal transition state leading to both (5 + 2) and (4 + 2) cycloaddition products.
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More for · 5
Mechanisms and Dynamics of Synthetic and Biosynthetic Formation of Delitschiapyrones: Solvent Control of Ambimodal Periselectivity.
2021 · cited by 14
Paper [1] demonstrates variable selectivity originating from a (4 + 2)/(4 + 3) ambimodal transition state.
Computational Design of a Tetrapericyclic Cycloaddition and the Nature of Potential Energy Surfaces with Multiple Bifurcations.
2023 · cited by 9
Paper [4] explores an ambimodal transition state leading to four different pericyclic reaction products.
Using the Theozyme Model to Study the Dynamical Mechanism of the Post-Transition State Bifurcation Reaction by NgnD Enzyme.
2024 · cited by 2
Paper [8] investigates post-transition state bifurcation where a single ambimodal transition state yields multiple adducts.
Molecular Dynamics of the Davies Ambimodal C-H Functionalization/Cope Rearrangement Reaction.
2024 · cited by 2
Paper [9] reports quasi-classical trajectories for a reaction proceeding via an ambimodal transition state toward multiple products.
Interplay between Energy and Entropy Mediates Ambimodal Selectivity of Cycloadditions.
2024 · cited by 2
Paper [11] analyzes how energy and entropy mediate the ambimodal selectivity of cycloadditions sharing a single transition state.