Certain antibiotics cause ototoxicity by damaging inner ear sensory cells
the verdict
SUPPORTED
the evidence backs this
confidence 88/100
Multiple peer-reviewed studies establish that certain classes of antibiotics, such as aminoglycosides and glycopeptides, cause ototoxicity by damaging and destroying inner ear sensory hair cells.
Evidence for · 6
Physiologic Status of Regenerated Hair Cells in the Avian Inner Ear following Aminoglycoside Ototoxicity
1990 · cited by 117
Demonstrates that the aminoglycoside antibiotic gentamicin causes hearing loss and ototoxicity via inner ear hair cell damage.
See more details
More for · 5
Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity.
2021 · cited by 55
Reviews acquired hearing loss from hospital-prescribed medications, highlighting aminoglycoside antibiotics as a major cause of ototoxicity.
Mechanisms of Ototoxicity and Otoprotection.
2021 · cited by 48
Discusses fundamental mechanisms of ototoxicity by clinically relevant medications, specifically citing aminoglycoside antibiotics.
Aminoglycosides-Related Ototoxicity: Mechanisms, Risk Factors, and Prevention in Pediatric Patients.
2023 · cited by 27
Notes that aminoglycosides cause permanent ototoxicity through toxic side effects acting on inner ear cells.
Glutamate-aspartate transporter dysfunction enhances aminoglycoside-induced cochlear hair cell death via NMDA receptor activation.
2023 · cited by 7
Evaluates gentamicin cytotoxicity and its reduction via feeding protocols, confirming aminoglycoside damage to cochlear and vestibular sensory hair cells.
TIGAR Protects Cochlear Hair Cells against Teicoplanin-Induced Damage
2023 · cited by 5
Shows that the antibiotic teicoplanin causes dose-dependent cell death in cochlear hair cells.