Specific chemical and electrochemical environments can enable carbonyl oxygen atoms to function as nucleophiles, as demonstrated by targeted mechanistic studies.
The claim is specific, empirical, and testable. Retrieved papers [0] and [5] provide experimental evidence and mechanistic support demonstrating that carbonyl oxygen atoms or their interactions can participate in nucleophilic pathways under specialized conditions (such as electro-oxidation and Lewis acid coordination). The remaining papers are tangential. Therefore, the claim is supported.