Carbohydrates are of no use for basal metabolic needs
Carbohydrates are essential for basal metabolic needs, providing key intermediates for energy, biosynthesis, and cellular redox balance, directly refuting the claim.
The claim states that carbohydrates are of no use for basal metabolic needs. Multiple papers, such as those detailing aerobic glycolysis [4] and the pentose phosphate pathway [9], show that carbohydrates (specifically glucose and its derivatives) play indispensable roles in cellular metabolism, energy production, biosynthesis, and redox balance. Therefore, the claim is clearly refuted by established biochemical evidence.
Sophia Y. Lunt, Matthew G. Vander Heiden. Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation. 2011. https://doi.org/10.1146/annurev-cellbio-092910-154237
Paper [4] highlights how glycolysis and carbohydrate intermediates are essential for meeting the metabolic requirements of cell proliferation and biomass construction.
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Anna Stincone, Alessandro Prigione, Thorsten Cramer, Mirjam M. C. Wamelink, Kate Campbell, Eric C. Cheung, Viridiana Olín‐Sandoval, Nana‐Maria Grüning, Antje Krüger, Mohammad Tauqeer Alam, Markus A. Keller, Michael Breitenbach, Kevin M. Brindle, Joshua D. Rabinowitz, Markus Ralser. The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. 2014. https://doi.org/10.1111/brv.12140
Paper [9] demonstrates that the pentose phosphate pathway, which metabolizes carbohydrates, is fundamental for maintaining carbon homeostasis, biosynthesis, and cellular redox balance.
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