Cancer cells can achieve cellular immortality in culture
the verdict
SUPPORTED
the evidence backs this
confidence 86/100
Cancer cells frequently achieve cellular immortality in culture through mechanisms such as telomerase reactivation or alternative telomere lengthening, which allow them to bypass normal replicative senescence.
Evidence for · 7
Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres
2017 · cited by 52
The paper discusses how incipient cancer cells bypass telomere-p53 barriers to up-regulate telomerase and achieve cellular immortality.
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More for · 6
Cellular immortalization and telomerase activation in cancer
2005 · cited by 2
The review notes that cancer development involves the selection of variant cells that survive and proliferate indefinitely.
CSIG-05. A GABP DOMINANT NEGATIVE APPROACH TO THE REVERSAL OF TUMOR IMMORTALITY
2022 · cited by 0
The study highlights immortality as a fundamental hallmark of human cancer cells driven by TERT promoter mutations.
Cell Immortalization: In Vivo Molecular Bases and In Vitro Techniques for Obtention.
2023 · cited by 0
The review details how cancer cells utilize telomerase activation or alternative lengthening mechanisms to obtain infinite replicative capacity in vitro and in vivo.
In vitro human cell line models to predict clinical response to anticancer drugs.
2015 · cited by 0
The paper notes the widespread use of immortalized cancer cell lines, such as the NCI-60 panel, in pharmacogenomic studies.
The significance of telomerase activation and cellular immortalization in human cancer.
2002 · cited by 0
The paper explains that immortalization and telomerase activation are necessary for continuous tumor cell proliferation and malignant progression.
Specific association of human telomerase activity with immortal cells and cancer.
1994 · cited by 0
The study demonstrates that human telomerase activity is specifically associated with immortal cells and the vast majority of human tumors.