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the claim
Calcium influx triggers the exocytosis of mast cell secretory granules.
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
5 sources for · 0 against

Multiple studies demonstrate that calcium influx and mobilization play a critical role in triggering the exocytosis of secretory granules in mast cells.

Evidence for · 5
Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms
2008 · cited by 185
Paper 0 details SNARE-mediated exocytosis in mast cells following receptor activation.
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The analysis

The retrieved literature contains multiple direct studies (such as direct microinjection of calcium and calcium ionophore experiments) and molecular analyses showing that calcium influx is a key trigger for mast cell degranulation. There is no contradictory evidence in the provided papers.

More for · 4
Cdc42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the Ip3/Calcium Pathway in Rbl-2h3 Mast Cells
2000 · cited by 125
Paper 1 demonstrates that Cdc42 and Rac regulate mast cell degranulation by stimulating the IP3/calcium pathway.
Exocytosis (Secretory Granule Extrusion) Induced by Injection of Calcium into Mast Cells
1973 · cited by 88
Paper 2 provides direct evidence that intracellular injection of calcium ions elicits the extrusion of secretory granules in mast cells.
Differential Regulation of Granule Release in Platelets and Immune Cells.
2026 · cited by 0
Paper 10 shows that ionomycin (a calcium ionophore) robustly stimulates mast cell granule release.
IKK2, calcium, MAP kinase, and PI3 kinase are required for exocytosis and interleukin-8 production in human mast cells stimulated by Trichomonas vaginalis-derived secretory products.
2026 · cited by 0
Paper 11 finds that calcium chelation reduces exocytosis markers in human mast cells.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoformspeer-reviewedsupports
  2. Cdc42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the Ip3/Calcium Pathway in Rbl-2h3 Mast Cellspeer-reviewedsupports
  3. Exocytosis (Secretory Granule Extrusion) Induced by Injection of Calcium into Mast Cellspeer-reviewedsupports
  4. Calcium mobilization and influx during sperm exocytosispeer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Nutrient regulation of the islet epigenome controls adaptive insulin secretion.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Mechanically induced dysregulation of calcium homeostasis: a molecular linchpin in asthmatic pathogenesis.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. The role of relaxins in blood cell modulation: interactions with relaxin family peptide receptor 1 (RXFP1) and glucocorticoid receptor (GR).peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Nociceptor neurons shape antiviral immunity.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Inorganic Polyphosphate: An Emerging Regulator of Neuronal Bioenergetics and Its Implications in Neuroprotection.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Differential Regulation of Granule Release in Platelets and Immune Cells.peer-reviewedsupports
  12. IKK2, calcium, MAP kinase, and PI3 kinase are required for exocytosis and interleukin-8 production in human mast cells stimulated by Trichomonas vaginalis-derived secretory products.peer-reviewedsupports
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → SUPPORTED · 8906 Aug 2026
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