Building a closed-loop ecological life support system is difficult due to complex ecosystem dynamics and unpredictable microbial imbalances.
Building closed-loop ecological life support systems remains difficult due to complex ecosystem dynamics and unpredictable biological and microbial responses under altered environmental conditions.
The retrieved papers consistently emphasize the complexities and technological hurdles involved in creating stable, closed-loop bioregenerative life support systems, noting difficulties in maintaining biological stability, managing nutrient cycles, and predicting organismal responses in space-like or closed environments. No papers refute the claim.
Alex Ellery. Supplementing Closed Ecological Life Support Systems with In-Situ Resources on the Moon. 2021. https://doi.org/10.3390/life11080770
Paper [0] reviews closed ecological life support systems (CELSS) and highlights the ongoing challenges in recycling key elements and managing bioregenerative methods.
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Nie H, Zhou W, Zheng Z, Deng Y, Zhang W, Zhang M, Jiang Z, Zheng H, Yuan L, Yang J, Wang H. Exploring plant responses to altered gravity for advancing space agriculture.. 2025. https://doi.org/10.1016/j.xplc.2025.101370
Paper [2] discusses the environmental challenges of space agriculture and maintaining stable bioregenerative life-support systems under altered gravity.
Volker Blüm, Michael Andriske, Karlheinz Kreuzberg, Martin P. Schreibman. The C.E.B.A.S. System: A Multi-Purpose Facility for Aquatic Man-Made Ecosystem and Bioregenerative Life Support System Research. 1994. https://doi.org/10.4271/941344
Paper [3] details the complexities of maintaining biological stability among fishes, plants, and microorganisms in a closed aquatic ecosystem.
Alan Drysdale. OCAM-2: A Second Generation Bioregenerative Life Support System Model. 1997. https://doi.org/10.4271/972291
Paper [6] models the movement of matter and management challenges in second-generation bioregenerative life support systems.
Fais G, Ghiani F, Dessì D, Casula M, Perra G, Torchia E, Lai N, Cao G, Concas A. Superfood potential of Chlorella vulgaris: productivity and antioxidant boost under simulated moon and microgravity conditions.. 2025. https://doi.org/10.1038/s41526-025-00550-4
Paper [11] emphasizes the vital role of Bioregenerative Life Support Systems (BLSS) in space missions while noting the physiological and biological adjustments organisms undergo in simulated moon and microgravity conditions.
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