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the claim
Bioinformatic tools like KEGG and MetaCyc can identify enzyme actions in metabolic pathways.
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
5 sources for · 0 against

Bioinformatic tools and databases such as KEGG and MetaCyc are widely utilized and documented in scientific literature for identifying enzyme actions and metabolic pathways.

Evidence for · 5
A systematic comparison of the MetaCyc and KEGG pathway databases
2013 · cited by 148
Paper compares the compound, reaction, and pathway content of MetaCyc and KEGG, demonstrating their use in identifying metabolic pathways and reactions.
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The analysis

The retrieved papers consistently demonstrate that KEGG and MetaCyc are primary bioinformatic databases and tools used by researchers to identify, reconstruct, and analyze metabolic pathways and enzyme actions across various organisms. Therefore, the claim is fully supported by the available evidence.

More for · 4
A Multi-Omics Analysis Pipeline for the Metabolic Pathway Reconstruction in the Orphan Species Quercus ilex
2018 · cited by 43
Paper uses the KEGG database to identify and visualize 123 metabolic pathways in the Holm oak genome.
Prediction of trehalose-metabolic pathway and comparative analysis of KEGG, MetaCyc, and RAST databases based on complete genome of Variovorax sp. PAMC28711
2022 · cited by 24
Paper uses KEGG and MetaCyc databases to deduce and identify the trehalose metabolic network and its enzymes.
Chemical representation standardization needed to generalize metabolic pathway involvement prediction across the Kyoto Encyclopedia of Genes and Genomes, Reactome, and MetaCyc knowledgebases
2025 · cited by 2
Paper notes that knowledgebases like KEGG and MetaCyc aggregate pathway and compound annotations to identify pathway involvement.
Inulin supplementation increases the differential metabolites and metabolic pathway in Baird's tapirs (Tapirus bairdii)
2023 · cited by 1
Paper utilizes KEGG annotation to identify differential metabolites and analyze metabolic pathways in Baird's tapirs.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. A systematic comparison of the MetaCyc and KEGG pathway databasespeer-reviewedsupports
  2. A review of computational tools for design and reconstruction of metabolic pathwayspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. A Multi-Omics Analysis Pipeline for the Metabolic Pathway Reconstruction in the Orphan Species Quercus ilexpeer-reviewedsupports
  4. Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interactionpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Prediction of trehalose-metabolic pathway and comparative analysis of KEGG, MetaCyc, and RAST databases based on complete genome of Variovorax sp. PAMC28711peer-reviewedsupports
  6. Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancerpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Deep learning for metabolic pathway design.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple continents, age groups, and body sites.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Chemical representation standardization needed to generalize metabolic pathway involvement prediction across the Kyoto Encyclopedia of Genes and Genomes, Reactome, and MetaCyc knowledgebasespeer-reviewedsupports
  10. Inulin supplementation increases the differential metabolites and metabolic pathway in Baird's tapirs (Tapirus bairdii)peer-reviewedsupports
  11. A Pipeline for Metabolic Pathway Reconstruction in Plant Orphan Species.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. A standardized workflow for kinetic metabolic model curation and dissemination.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → SUPPORTED · 8806 Aug 2026
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