Extensive chemical literature consistently characterizes benzyne (and arynes generally) as high-energy, reactive chemical intermediates that are generated from various precursors and rapidly trapped or polymerized.
Evidence for · 11
Free carbenes from complementarily paired alkynes.
2024 · cited by 8
Paper 0 describes arynes as high-energy, reactive intermediates.
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More for · 10
Aryne Generation from Aryl Halides Via Photothermal Red-Light Activation.
2025 · cited by 2
Paper 1 discusses the generation and trapping of high-energy aryne intermediates.
An Untethered and Formal Intermolecular Hexadehydro-Diels-Alder Reaction: Alkynylboronates with 2-(1,3-Butadiynyl)pyridines.
2024 · cited by 2
Paper 2 demonstrates the formation of benzyne intermediates captured by trapping agents.
Rapid (≤25 °C) cycloisomerization of anhydride-tethered triynes to benzynes - origin of a remarkable anhydride linker-induced rate enhancement.
2025 · cited by 2
Paper 3 details hexadehydro-Diels-Alder reactions generating ortho-benzyne derivatives.
Mechanisms of Kobayashi eliminations for the generation of highly strained arynes, cyclic cumulenes, and anti-Bredt olefins.
2025 · cited by 1
Paper 4 examines transient strained intermediates, specifically benzyne, via Kobayashi eliminations.
Cycloadditions of Benzynes with the Azoxy [RN═N<sup>+</sup>(O<sup>-</sup>)R'] 1,3-Dipole Tautomer of 1-Hydroxybenzotriazole (HOBT).
2024 · cited by 1
Paper 5 explores cycloadditions of thermally generated benzynes as reactive species.
Copper-mediated stepwise polymerization of benzynes: construction of amphiphilic block copolymers and their self-assembly in water.
2026 · cited by 0
Paper 7 describes the direct polymerization of benzynes generated from precursors.
How Alkali Metal Alkoxides Initiate Organic Radical Reactions.
2026 · cited by 0
Paper 8 shows that deprotonation leads to benzynes that initiate radical chemistry.
1<i>H</i>-Isoindolynes: Arynes Accessible by a One-Pot, Ambient Temperature, Three-Component Cascade.
2026 · cited by 0
Paper 9 introduces isoindolynes as a new type of aryne generated via cascade reactions.
Ring-Opening Arylation of Cyclic Diaryliodoniums via Cyclic Triaryliodanes as Aryne Precursors and Dynamic Aryl Reservoirs.
2026 · cited by 0
Paper 10 notes the use of cyclic diaryliodoniums as precursors to arynes.
Biomimetic Synthesis of Seven Halenaquinone Meroterpenoids.
2026 · cited by 0
Paper 11 utilizes an aryne-furan Diels-Alder reaction to construct complex carbon frameworks.