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the claim

Being underweight influences an individual's risk of developing cancer

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Multiple clinical and epidemiological studies demonstrate that being underweight influences cancer risk, prognosis, and mortality.

The analysis

The retrieved literature includes several robust cohort studies and mechanistic investigations showing that low body mass index (BMI) or underweight status is significantly associated with cancer outcomes, including increased risk of specific cancers (such as gastric cancer), altered metastatic patterns (such as brain metastasis in lung cancer), and elevated cancer mortality.

Evidence for · 4
Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI
Recorded source metadata

Abhishek Tyagi, Shih-Ying Wu, Jee-Won Kim, R. Deshpande, Kerui Wu, Eleanor C Smith, G. Banna, Kounosuke Watabe. Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI. 2025. https://doi.org/10.1038/s41467-025-60730-4

Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI.

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More for · 3
Association Between Body Mass Index and Overall Survival in Patients With Colorectal Cancer in Taiwan.
Recorded source metadata

Kuo TC, Wang WC, Hsiao WP, Yen Y, Yeh CC. Association Between Body Mass Index and Overall Survival in Patients With Colorectal Cancer in Taiwan.. 2026. https://doi.org/10.21873/anticanres.18273

Underweight status was associated with higher mortality among colorectal cancer patients in Taiwan.

Body Mass Index and Risks of More Than 40 Cause-Specific Mortality in Chinese Women: A Prospective Cohort Study.
Recorded source metadata

Hu J, Ke Y, Yu C, Sun D, Pang Y, Pei P, Yang L, Chen Y, Du H, Chang X, Barnard M, Chen J, Chen Z, Li L, Lv J. Body Mass Index and Risks of More Than 40 Cause-Specific Mortality in Chinese Women: A Prospective Cohort Study.. 2026. https://doi.org/10.1002/jcsm.70330

Underweight was linked to an increased risk of neoplasm-related mortality in a large prospective cohort study.

Body mass index change trajectories and gastric cancer risk: Effect modification by sex, age, smoking, and menopausal status in Korean adults aged ≥40 years.
Recorded source metadata

Nam SY, Jo J. Body mass index change trajectories and gastric cancer risk: Effect modification by sex, age, smoking, and menopausal status in Korean adults aged ≥40 years.. 2026. https://doi.org/10.1371/journal.pone.0350626

Both underweight and persistent obesity were associated with an increased gastric cancer risk in specific subgroups.

The paper trail · every fact has a biography
first checked01 Aug 2026
judged → SUPPORTED · 8101 Aug 2026
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