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the claim

Base stacking interactions confer primary thermodynamic stability to the DNA double helix

the verdict

SUPPORTED

the evidence backs this

confidence 78/100

Biophysical evidence confirms that base-stacking interactions between aromatic nucleobases inside the double helix play a fundamental role in conferring thermodynamic stability to the DNA structure.

Evidence for · 2

Differences and Similarities in Protein and Nucleic Acid Structures and Their Biological Interactions.

2025 · cited by 2

Paper 0 notes that hydrophobic and aromatic nucleobase side chains are located inside the double helix, highlighting the architectural significance of base stacking.

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More for · 1

Investigating Polarity Effects in DNA Base Stacking.

2025 · cited by 1

Paper 3 investigates nucleic acid structures and affirms that they are stabilized by both base pairing and base stacking interactions.

The paper trail · every fact has a biography

first checked01 Aug 2026

judged → SUPPORTED · 7801 Aug 2026

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