Evidence establishes that bacteria can and do develop resistance to natural antimicrobial compounds and peptides through evolutionary adaptation and pre-existing resistance mechanisms.
The retrieved literature consistently supports the claim that bacteria develop resistance to natural antibiotics and antimicrobial peptides. Papers 0, 1, and 2 directly discuss how bacteria evolve or harbor resistance mechanisms against natural products and peptides, while the remaining papers focus on finding ways to overcome or mitigate this resistance using natural derivatives or combinations. No paper refutes the claim.