Axons use molecular recognition molecules to avoid self-synapsing with their own neuron
the verdict
SUPPORTED
the evidence backs this
confidence 82/100
Axons and neurons utilize cell surface molecular recognition molecules, such as Dscam and protocadherins, to provide unique cellular identities and mediate self-avoidance or prevent self-synapsing.
Evidence for · 3
Revisiting Dscam diversity: lessons from clustered protocadherins.
2019 · cited by 15
Discusses how extraordinary recognition diversity of cell surface molecules like Dscam and clustered protocadherins prevents inappropriate interactions and wires neural circuits.
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More for · 2
A systematic CRISPR screen reveals redundant and specific roles for Dscam1 isoform diversity in neuronal wiring.
2023 · cited by 4
Demonstrates that diverse isoforms of cell adhesion molecules such as Dscam1 are critical for self-discrimination and proper axonal patterning.
Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis.
2025 · cited by 2
Highlights how transmembrane receptors like Dscam use extensive isoform diversity and homophilic interactions to establish unique cellular identities and avoid incorrect connectivity.