Antidepressants have a delayed onset of action due to neuroplastic adaptation processes
the verdict
SUPPORTED
the evidence backs this
confidence 92/100
Multiple studies and reviews support the concept that conventional antidepressants have a delayed therapeutic onset because they rely on gradual neuroplastic adaptations, such as altered BDNF signaling and synaptic rewiring.
Evidence for · 3
Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action.
2021 · cited by 429
Paper 0 links antidepressant action and mood disorders to neurotrophic factors and neuronal plasticity mechanisms like BDNF signaling.
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More for · 2
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression.
2018 · cited by 0
Paper 6 notes that while traditional antidepressants still exhibit a delayed onset of action, they exert beneficial therapeutic effects by enhancing neurotrophic signaling and synaptic plasticity.
Antidepressant drug action--From rapid changes on network function to network rewiring.
2016 · cited by 0
Paper 8 associates the delayed onset of monoamine-based antidepressants with their slow ability to increase synaptic plasticity and neuronal excitability via altered neurotrophic signaling.