An inhibitory tone refers to a continuous baseline level of inhibitory synaptic activity in neurons
the verdict
SUPPORTED
the evidence backs this
confidence 86/100
Neuroscientific studies confirm that an inhibitory tone represents a continuous baseline level of inhibitory synaptic or extrasynaptic activity that controls neuronal excitability and firing.
Evidence for · 5
Dissociation of spikes, synaptic activity, and activity-dependent increments in rat cerebellar blood flow by tonic synaptic inhibition
2003 · cited by 65
Paper 2 discusses tonic synaptic inhibition as a baseline level of activity that regulates neuronal excitability.
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More for · 4
Study of GABAergic extra-synaptic tonic inhibition in single neurons and neural populations by traversing neural scales: application to propofol-induced anaesthesia
2014 · cited by 40
Paper 4 examines tonic inhibitory currents and their steady-state modulation of neuronal firing rates.
Tonic GABAergic inhibition, via GABAA receptors containing αβƐ subunits, regulates excitability of ventral tegmental area dopamine neurons
2021 · cited by 15
Paper 6 describes tonic GABAergic input as a persistent ambient current that regulates baseline neuronal excitability.
Enhancing GABAergic Tonic Inhibition Reduces Seizure-Like Activity in the Neonatal Mouse Hippocampus and Neocortex
2024 · cited by 10
Paper 7 notes that neurons exhibit tonic inhibitory conductances that reduce baseline neuronal firing.
Induction of inhibitory synaptic plasticity enhances tonic current by increasing the content of α5-subunit containing GABAA receptors in hippocampal pyramidal neurons.
2021 · cited by 9
Paper 8 states that tonic currents provide a persistent component of inhibitory drive representing the majority of total inhibitory charge.