Altitude-related secondary polycythemia increases blood thickness
Evidence consistently shows that altitude-related secondary polycythemia increases red blood cell mass and hematocrit, which in turn leads to increased whole blood viscosity.
The claim is specific and falsifiable, meeting Step 0 requirements. Retrieved papers such as [2] and [11] explicitly examine high-altitude polycythemia and confirm that elevated red blood cell parameters lead to increased blood thickness (viscosity).
Chen K, Li N, Fan F, Geng Z, Zhao K, Wang J, Zhang Y, Tang C, Wang X, Meng X. Tibetan Medicine Duoxuekang Capsule Ameliorates High-Altitude Polycythemia Accompanied by Brain Injury.. 2021. https://doi.org/10.3389/fphar.2021.680636
Paper [2] confirms that chronic hypobaric hypoxia leads to elevated RBC, hemoglobin, hematocrit, and whole blood viscosity.
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Priti Azad, Gabriel Haddad. Molecular Basis of Hypoxia Induced Excessive Erythrocytosis. 2017. https://doi.org/10.1096/fasebj.31.1_supplement.709.5
Paper [11] notes that while high-altitude polycythemia increases oxygen-carrying capacity, it also causes the blood to increase its viscosity.
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