Evidence from clinical studies demonstrates that alternate-day iron supplementation increases iron absorption and improves fractional uptake compared to consecutive daily dosing, largely by avoiding sustained hepcidin elevations.
The retrieved literature contains specific studies and reviews (such as papers [0] and [8]) investigating iron supplementation regimens, confirming that alternate-day dosing improves fractional absorption and reduces hepcidin concentrations relative to daily dosing. No papers refute this physiological mechanism.