Altered clotting factors contribute to the development of avascular necrosis
the verdict
SUPPORTED
the evidence backs this
confidence 84/100
Multiple clinical reviews and studies demonstrate that coagulopathies, thrombotic events, and altered clotting factors play a major role in causing the localized ischemia that leads to avascular necrosis.
Evidence for · 5
A Molecular Troika of Angiogenesis, Coagulopathy and Endothelial Dysfunction in the Pathology of Avascular Necrosis of Femoral Head: A Comprehensive Review.
2023 · cited by 22
Paper 0 establishes that coagulopathy and thrombus formation are key elements of the molecular triad contributing to the pathology of avascular necrosis of the femoral head.
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More for · 4
Osteonecrosis of the Jaws in Patients with Hereditary Thrombophilia/Hypofibrinolysis-From Pathophysiology to Therapeutic Implications.
2022 · cited by 8
Paper 1 finds that thrombotic occlusion and hereditary prothrombotic abnormalities significantly contribute to osteonecrosis development and treatment refractoriness.
Avascular Necrosis of the Femoral Head in Patients with Antiphospholipid Syndrome: A Case Series.
2025 · cited by 5
Paper 2 demonstrates through a clinical case series that avascular necrosis can manifest as a complication in systemic conditions like antiphospholipid syndrome characterized by thrombosis.
Bilateral Avascular Necrosis of the Femoral Heads in Ankylosing Spondylitis Requiring Staged Total Hip Arthroplasty: A Case Report of Diagnostic and Therapeutic Challenges.
2026 · cited by 0
Paper 7 notes that a prothrombotic state is a recognized factor in the multifactorial pathogenesis of avascular necrosis in patients with ankylosing spondylitis.
Association of <i>IL-23R</i> rs1569922 and Other Probable Frequent Etiological Factors with Legg-Calvé-Perthes Disease in Mexican Patients.
2025 · cited by 0
Paper 10 reports that patients with Legg-Calvé-Perthes disease (a form of avascular osteonecrosis) exhibit hypercoagulable states and alterations in hemostatic factors.