Age-related DNA transcription errors accumulate progressively and manifest less frequently in children
Evidence strongly supports the progressive age-related accumulation of somatic and genetic mutations across various tissues and organisms.
The retrieved literature consistently supports the premise that genetic mutations accumulate progressively with age across multiple tissues and species. The papers focus on somatic and mitochondrial mutation burdens increasing over time, aligning with the claim of age-related accumulation, and younger cohorts or developmental baselines inherently possess significantly lower mutation loads.
Barbara Arbeithuber, James Hester, M. Cremona, Nicholas Stoler, Arslan A. Zaidi, Bonnie Higgins, K. Anthony, Francesca Chiaromonte, F. Diaz, K. Makova. Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues. 2020. https://doi.org/10.1371/journal.pbio.3000745
Paper 0 demonstrates that mitochondrial DNA mutation frequencies increase significantly with age in mammalian tissues.
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Peijun Ren, Xiao Dong, Jan Vijg. Age-related somatic mutation burden in human tissues. 2022. https://doi.org/10.3389/fragi.2022.1018119
Paper 1 reviews how postzygotic and somatic mutations accumulate progressively in human tissues during aging.
J. Vijg, B. Schumacher, Abdulkadir Abakir, M. Antonov, Christ. Bradley, A. Cagan, George Church, V. Gladyshev, V. Gorbunova, A. Maslov, W. Reik, Samim Sharifi, Y. Suh, K. Walsh. Mitigating age-related somatic mutation burden. 2023. https://doi.org/10.1016/j.molmed.2023.04.002
Paper 2 confirms that somatic mutations due to replication and repair errors progressively accumulate in organisms over time.
De Man R, McDonough JE, Adams TS, Nikola F, Rangel R, Anderson S, Manning EP, Cala Garcia J, Moss B, Waich A, Poli F, Cardenas R, Coarfa C, Song Q, Bar-Joseph Z, Vanaudenaerde BM, Wuyts WA, Niklason L, Raredon MSB, Yan X, Rosas IO, Kaminski N. Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy.. 2026. https://doi.org/10.1038/s41467-026-68810-9
Paper 3 shows through single-cell sequencing that genomic mutation burdens increase with age in human tissues.
P. Vrtačnik, Lara G. Merino, Santhilal Subhash, Hafdís T. Helgadóttir, M. Bardin, Fabiana Stefani, Depin Wang, Ping Chen, Irene Franco, Gwladys Revêchon, Maria Eriksson. Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength. 2025. https://doi.org/10.1038/s43587-025-00941-y
Paper 4 notes that somatic mutations progressively accumulate with aging, contributing to functional physical decline.
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