Aerobic and resistance training have different effects on cognition
Aerobic and resistance training both benefit cognitive function, but they operate through distinct physiological mechanisms and target different aspects of cognition.
The retrieved literature supports the claim that aerobic and resistance training have different effects on cognition. While both modalities improve cognitive performance and counteract age-related decline, reviews and comparative studies (such as papers 1 and 9) demonstrate that they engage different molecular pathways (such as specific neurotrophic factors and signaling cascades) and can differentially impact specific cognitive domains like memory versus executive function.
Wissem Dhahbi, Walid Briki, A. Heissel, L. Schega, Ismail Dergaa, N. Guelmami, Abdelfettah El Omri, H. Chaabène. Physical Activity to Counter Age-Related Cognitive Decline: Benefits of Aerobic, Resistance, and Combined Training—A Narrative Review. 2025. https://doi.org/10.1186/s40798-025-00857-2
Paper 1 provides a comprehensive review showing that aerobic and resistance exercises influence cognitive function and mental health through distinct mechanisms, types, and intensities.
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Shotaro Izawa, K. Nishii, Naoki Aizu, Takumi Kito, Daiki Iwata, Takeshi Chihara, Hirohide Sawada, Runhong Yao, Kouji Yamada. Effects of Aerobic Exercise and Resistance Training on Cognitive Function: Comparative Study Based on FNDC5/Irisin/BDNF Pathway. 2024. https://doi.org/10.1159/000541093
Paper 9 directly verifies that while both aerobic and resistance training suppress age-related cognitive decline, they rely on differing underlying molecular pathways in the hippocampus.
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