Advanced maternal age increases the statistical probability of Down syndrome pregnancies
the verdict
SUPPORTED
the evidence backs this
confidence 88/100
Multiple studies and clinical data confirm that advanced maternal age significantly increases the statistical probability of pregnancies affected by Down syndrome due to elevated rates of chromosomal nondisjunction.
Evidence for · 5
The maternal age‐specific live birth prevalence of trisomies 13 and 18 compared to trisomy 21 (Down syndrome)
2009 · cited by 104
Morris et al. (2009) establish maternal age-specific live birth prevalence rates for trisomy 21 and other trisomies.
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More for · 4
On the origin of the maternal age effect in trisomy 21 Down syndrome: the Oocyte Mosaicism Selection model
2010 · cited by 40
Berríos et al. (2010) discuss the oocyte mosaicism selection model to explain the well-documented maternal age effect in Down syndrome.
Etiology of Down Syndrome: Risk of Advanced Maternal Age and Altered Meiotic Recombination for Chromosome 21 Nondisjunction
2011 · cited by 3
Biswas et al. (2011) identify advanced maternal age as a primary risk factor for chromosome 21 nondisjunction and Down syndrome.
Impact of Biological Factors Related to Maternal Aging: Risk of Childbirth with Down Syndrome
2020 · cited by 2
Jahan et al. (2020) review the biological mechanisms linking advanced chronological age and ovarian aging to trisomy 21.
Incidence of aneuploidy in embryos studied using PGT-A in Mexico: a clinical retrospective experience.
2025 · cited by 1
García-López et al. (2025) report that the incidence of embryonic aneuploidy, including trisomy 21, significantly increases with advancing maternal age.