Adult mammalian brain cells undergo neurogenesis over time
Extensive scientific literature confirms that adult mammalian brain cells undergo neurogenesis over time, predominantly within specific neurogenic niches such as the subventricular zone and the dentate gyrus.
The retrieved papers consistently support the well-established biological fact that adult mammalian brains undergo neurogenesis in specific regions like the hippocampus and subventricular zone. Multiple reviews and experimental studies document the presence of adult neural stem cells and the ongoing generation of new neurons across various mammalian species.
Betters RK, Manly RW, Huynh PM, Tunc-Ozcan E. Extent and activity of adult hippocampal neurogenesis.. 2025. https://doi.org/10.3389/fnins.2025.1709208
This study discusses how hippocampal neurogenesis persists in mammals and contributes to learning, memory, and emotional regulation.
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Wang XT, Wang J, Zhao XJ. Exercise training promotes neurogenesis in the adult hippocampus with a particular focus on cell cycle regulation.. 2026. https://doi.org/10.3389/fspor.2026.1770350
The paper confirms that adult neurogenesis occurs in specific neurogenic regions of the mammalian brain, such as the subgranular zone.
Baudry M, Reece T, Shahi R, Ta K, Bi X. Calpain-2 Inhibition or Deletion Enhances Levels of the Transcription Factor, MEIS2, and Stimulates Neurogenesis.. 2026. https://doi.org/10.2174/011570159x421552260330191235
Research indicates that neurogenesis takes place in the subventricular zone and dentate gyrus of adult mammalian species.
Li S, Shi X, Sun XL, Wu QF. Adult neural stem cell pools in homeostasis and pathogenesis.. 2026. https://doi.org/10.1016/j.semcdb.2026.103685
This review highlights that adult neural stem cells persist throughout life in discrete neurogenic niches, maintaining lifelong neurogenesis.
D'Andrea G, Bertini L, Costanzi M, Canini F, Bernini R, Fochetti A, Clemente M, Proietti S, Ceccarelli M, Caruso C, Caruso M, Scavizzi F, Raspa M, Tirone F, Micheli L. Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition.. 2026. https://doi.org/10.1111/jnc.70448
The findings show that therapeutic interventions can counteract age-associated declines by promoting new neuron production in the adult mammalian brain.
Burciaga-Paez JY, Garza-Veloz I, Martinez-Fierro ML. The Current Landscape of Adult Neural Stem Cell Research: A Narrative Review.. 2026. https://doi.org/10.3390/cells15090779
This review confirms that adult neural stem cells maintain lifelong neurogenesis, a fundamental process for brain homeostasis.
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