Evidence from multiple studies indicates that although calorie restriction and rapamycin share some downstream geroprotective benefits, they engage distinctly different molecular pathways and gene expression patterns.
The retrieved papers consistently show that calorie restriction and rapamycin operate through both overlapping and distinct molecular mechanisms, specifically noting unique pathway engagement in skeletal muscle and gene expression patterns. Therefore, the claim that administration of rapamycin differs from calorie restriction in specific molecular pathways is fully supported.