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the claim
A small number of loci explain the majority of phenotypic fitness variance
the verdict
REFUTED
the evidence says no
confidence 18/100

The claim that a small number of loci explain the majority of phenotypic fitness variance is refuted by genomic and quantitative genetics literature, which consistently demonstrates that complex traits are highly polygenic and shaped by numerous loci with small effects.

Evidence against · 2
Polygenic adaptation and negative selection across traits, years and environments in a long‐lived plant species (Pinus pinaster Ait., Pinaceae)
2022 · cited by 27
Most complex traits are determined by numerous loci, each with a small effect size.
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More against · 1
Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.
2026 · cited by 5
Phenotypes arise from complex networks of many interdependent genes rather than a small number of loci.
The paper trail · every fact has a biography
first checked01 Aug 2026
judged → REFUTED · 1801 Aug 2026
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