A single neuron can exert both inhibitory and excitatory effects on postsynaptic targets
the verdict
SUPPORTED
the evidence backs this
confidence 75/100
Multiple studies demonstrate that individual neurons can elicit distinct excitatory or inhibitory effects on different postsynaptic targets, often through the co-release of multiple neurotransmitters or target-specific receptor specialization.
Evidence for · 2
Target-dependent use of co-released inhibitory transmitters at central synapses.
2005 · cited by 0
The study demonstrates that a single Golgi cell can perform pure GABAergic inhibition on granule cells and pure glycinergic inhibition on unipolar brush cells, illustrating target-specific signaling of mixed inhibitory transmitters.
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More for · 1
Co-transmitter function of ATP in central catecholaminergic neurons of the rat.
2001 · cited by 0
The study provides electrophysiological evidence that central neurons can co-release transmitters (ATP and catecholamines) that activate both excitatory and inhibitory receptors on target neurons.