A quantifiable fraction of human proteins have experimentally solved 3D structures.
the verdict
SUPPORTED
the evidence backs this
confidence 92/100
A quantifiable fraction of human proteins possess experimentally solved 3D structures, forming a substantial baseline of structural coverage that has recently been complemented by high-accuracy computational predictions.
Evidence for · 3
Can Predicted Protein 3D Structures Provide Reliable Insights into whether Missense Variants Are Disease Associated?
2019 · cited by 450
Paper 0 notes that baseline experimental structural coverage accounts for a substantial fraction of the human proteome before adding homology predictions.
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More for · 2
The structural coverage of the human proteome before and after AlphaFold
2021 · cited by 5
Paper 5 reports that the baseline structural coverage of the human proteome from experimentally derived or template-based models was already at 48% prior to the inclusion of AlphaFold predictions.
RCSB Protein Data Bank (PDB): Driving Research and Education Using Experimentally-Determined Structures and Computed Structure Models from Artificial Intelligence/Machine Learning
2025 · cited by 1
Paper 7 details how the RCSB Protein Data Bank houses hundreds of thousands of experimentally determined 3D macromolecular structures alongside computed models.