A person's sequenced genome provides clinically actionable utility today
the verdict
SUPPORTED
the evidence backs this
confidence 92/100
Current clinical evidence demonstrates that sequenced genomes provide actionable utility today, particularly in diagnosing rare pediatric conditions and guiding targeted precision oncology treatments.
Evidence for · 3
Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases
2018 · cited by 643
Whole-genome and exome sequencing demonstrate established clinical utility and alter medical management in pediatric genetic diseases.
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More for · 2
Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging
2020 · cited by 125
A prospective precision medicine cohort study found that whole-genome sequencing identifies actionable pathogenic variants and genotype-phenotype associations in a significant portion of adults.
Clinical application of whole-genome sequencing of solid tumors for precision oncology
2024 · cited by 15
A prospective study on solid tumors shows that whole-genome sequencing yields clinically relevant insights regarding therapeutic options and clinical management in practice.