A medical condition exists where individuals cannot feel physical pain.
the verdict
SUPPORTED
the evidence backs this
confidence 75/100
Medical conditions such as congenital insensitivity to pain (CIP) and congenital insensitivity to pain with anhidrosis (CIPA) are well-documented genetic disorders where individuals completely lack the ability to perceive physical pain.
Evidence for · 6
Novel deep intronic variants in <i>NTRK1</i> underlying congenital insensitivity to pain with anhidrosis.
2026 · cited by 0
This study discusses congenital insensitivity to pain with anhidrosis (CIPA), a genetic condition characterized by the inability to feel pain.
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More for · 5
[Congenital insensitivity to pain caused by a novel SCN9A-genotype].
2026 · cited by 0
The paper documents congenital insensitivity to pain (CIP), an extremely rare genetic disorder where individuals cannot sense physical pain.
Early clinical diagnosis of congenital insensitivity to pain with anhidrosis in an infant: a case report.
2026 · cited by 0
This case report details congenital insensitivity to pain with anhidrosis, confirming the clinical manifestation of profound pain insensitivity.
What a pain! The elusive management of an individual patient with SCN9A sodium channelopathy in the perioperative setting.
2026 · cited by 0
The article reviews SCN9A sodium channelopathies that result in hypoactive pain phenotypes, specifically congenital insensitivity to pain.
Identification and Functional Characterization of Novel and Recurrent NTRK1 Variants in Chinese Families With Congenital Insensitivity to Pain With Anhidrosis: A Combined Clinical, Genetic, and Functional Study.
2026 · cited by 0
This research investigates NTRK1 variants responsible for congenital insensitivity to pain with anhidrosis.
A Novel Inflammatory Autoimmune-Like <i>NTRK1</i>-Associated Phenotype in an Adult Man.
2025 · cited by 0
The case report presents an adult patient with congenital insensitivity to pain with anhidrosis (CIPA) caused by NTRK1 mutations.