A medical condition exists where individuals cannot feel physical pain.
Medical conditions such as congenital insensitivity to pain (CIP) and congenital insensitivity to pain with anhidrosis (CIPA) are well-documented genetic disorders where individuals completely lack the ability to perceive physical pain.
The claim states that a medical condition exists where individuals cannot feel physical pain. Multiple retrieved papers describe rare genetic conditions such as congenital insensitivity to pain (CIP) and congenital insensitivity to pain with anhidrosis (CIPA), which directly fulfill this criterion. Thus, the evidence strongly supports the claim.
Chen X, Li S, Liu Z, Cheng J, Ren X, Zhao X. Novel deep intronic variants in <i>NTRK1</i> underlying congenital insensitivity to pain with anhidrosis.. 2026. https://doi.org/10.3389/fgene.2026.1852317
This study discusses congenital insensitivity to pain with anhidrosis (CIPA), a genetic condition characterized by the inability to feel pain.
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Bjornsson T, Olafsson E, Katrinardottir H, Sigurdsson A, Arnadottir GA, Jensson B, Oddsson A, Vikingsson A, Bjornsdottir G, Thorgeirsson TE, Sulem P, Sveinsson OA. [Congenital insensitivity to pain caused by a novel SCN9A-genotype].. 2026. https://doi.org/10.17992/lbl.2026.06.897
The paper documents congenital insensitivity to pain (CIP), an extremely rare genetic disorder where individuals cannot sense physical pain.
Tang Z, Xu F, Zhang P, Zhang J, Kang X, Zhao H. Early clinical diagnosis of congenital insensitivity to pain with anhidrosis in an infant: a case report.. 2026. https://doi.org/10.3389/fped.2026.1844909
This case report details congenital insensitivity to pain with anhidrosis, confirming the clinical manifestation of profound pain insensitivity.
Wadle M, Szafarowicz B, Nykiel-Bailey S, Tan B, AuBuchon J, Njoku D. What a pain! The elusive management of an individual patient with SCN9A sodium channelopathy in the perioperative setting.. 2026. https://doi.org/10.1097/j.pain.0000000000004026
The article reviews SCN9A sodium channelopathies that result in hypoactive pain phenotypes, specifically congenital insensitivity to pain.
Ren Y, Cao Y, Cheng F, Dai J, Zhang Y, Wang X, Chen J, Zhou L, Song X, Wang H. Identification and Functional Characterization of Novel and Recurrent NTRK1 Variants in Chinese Families With Congenital Insensitivity to Pain With Anhidrosis: A Combined Clinical, Genetic, and Functional Study.. 2026. https://doi.org/10.1111/ene.70610
This research investigates NTRK1 variants responsible for congenital insensitivity to pain with anhidrosis.
Karabinos A, Tomkova E, Sprincova A, Tothova K, Repiska V, Jesenak M, Krizan P. A Novel Inflammatory Autoimmune-Like <i>NTRK1</i>-Associated Phenotype in an Adult Man.. 2025. https://doi.org/10.1159/000549961
The case report presents an adult patient with congenital insensitivity to pain with anhidrosis (CIPA) caused by NTRK1 mutations.
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