Large-scale systematic reviews and randomized clinical trials indicate that daily multivitamin supplementation does not provide significant health benefits, such as reducing cardiovascular disease or fracture risk, for healthy adults.
Evidence against · 2
Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease
2018 · cited by 62
This meta-analysis demonstrates that multivitamin and mineral supplementation does not improve cardiovascular outcomes or reduce mortality in the general population.
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More against · 1
Effects of cocoa extract supplementation and multivitamin/multimineral supplements on self-reported fractures in the Cocoa Supplement and Multivitamins Outcomes Study randomized clinical trial
2025 · cited by 3
This randomized clinical trial found that multivitamin/multimineral supplementation does not reduce the risk of clinical fractures or nonvertebral fractures in older adults.